37 results about "Genetic short stature" patented technology

The present invention relates to characterizing changes in mammalian gastrointestinal microbiota associated with antibiotic treatment and various disease conditions (such as obesity, metabolic syndrome, insulin-deficiency or insulin-resistance related disorders, glucose intolerance, diabetes, non-alcoholic fatty liver, abnormal lipid metabolism, short stature, osteoporosis, and other disorders of bone formation and mineralization, etc.) and related diagnostic and therapeutic methods. Therapeutic methods of the invention involve the use of probiotics, prebiotics, or narrow spectrum antibiotics / anti-bacterial agents that are capable of restoring healthy mammalian bacterial gastrointestinal microbiota.

The invention provides compounds of Formula (I) or prodrugs thereof, or pharmaceutically acceptable salts of said compounds or prodrugs, or solvates of said compounds, prodrugs or salts, wherein A, N, X and R1 are as defined herein; pharmaceutical compositions thereof; and methods of using the pharmaceutical compositions for the treatment of diseases, including Type 2 diabetes, Type 1 diabetes, impaired glucose tolerance, hyperglycemia, metabolic syndrome (syndrome X and / or insulin resistance syndrome), glucosuria, metabolic acidosis, arthritis, cataracts, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, obesity, conditions exacerbated by obesity, hypertension, hyperlipidemia, atherosclerosis, osteoporosis, osteopenia, frailty, bone loss, bone fracture, acute coronary syndrome, short stature due to growth hormone deficiency, infertility due to polycystic ovary syndrome, anxiety, depression, insomnia, chronic fatigue, epilepsy, eating disorders, chronic pain, alcohol addiction, diseases associated with intestinal motility, ulcers, irritable bowel syndrome, inflammatory bowel syndrome; short bowel syndrome; and the prevention of disease progression in Type 2 diabetes.

This invention provides a composition for increasing a body height of a patient with short stature or an individual other than patients with short stature. More specifically, the invention provides: a composition for increasing the body height of an individual comprising a guanyl cyclase B (GC-B) activator as an active ingredient, the composition being to be administered to an individual free from FGFR3 abnormality; a method for increasing the body height of an individual free from FGFR3 abnormality which comprises activating GC-B; a method for screening an agent for increasing the body height of an individual which comprises selecting an agent for increasing the body height using GC-B activity as an indication; and a method for extending a cartilage bone free from FGFR3 abnormality which comprises activating GC-B in an individual.

The invention discloses a method for breeding novel high-efficiency superior yellow-feathered broilers. The method comprises the following breeding steps: a Chinese local variety strain with high growing speed, yellow feather, neat and uniform body and appearance and even body weight is selected as a terminal male parent of the broilers; an individual with yellow feather, precocity property, high egg-laying rate and high uniformity is selected to be taken as a first female parent of the broilers; a strain with yellow feather, grain-saving property, short stature genes, laying rate of 90% during peak period and neat and uniform body and appearance is selected as a first male parent of the broilers; the first male parent cock and the first female parent hen are hybridized to form a second female parent of the novel broilers; the second female parent has yellow feather, can save grain by 25% when compared with common high-quality cocks and hens, and has average egg-laying rate above 10% higher than that of common high-quality hens; and the terminal male cock and the second female hen are hybridized, so as to obtain the commercial high-efficiency superior yellow-feathered broilers.

Various wares are provided which alone and in combination with one another facilitate entry of a person into the cargo area of a vehicle, such as a pickup truck bed. A bumper is provided having increased access at its end portions and center, which function as steps in providing a first stepping level and a second stepping level. In combination with grab handles provided, entry of the cargo area of a vehicle is greatly facilitated, especially in the cases of vehicles having high suspension systems, and in cases of individuals of relatively short stature.

The invention discloses a composition for noninvasive screening of an early lung cancer and application of the composition. The composition comprises three pairs of methylation-specific primer probes of SHOX2 (Short Stature Homebox2) genes, three pairs of methylation-specific primers of PTGER4 (Prostaglandin E Receptor 4) genes and one pair of reference gene primer probes and further comprises three MGB probes corresponding to non-methylation target genes in the SHOX2 genes and three MGB probes corresponding to the non-methylation target genes in the PTGER4 genes. A methylation detection kit for the noninvasive screening of the early lung cancer comprises the composition. Patients suffering from the early lung cancer are screened by detecting promoters of the SHOX2 genes and the PTGER4 genes of free DNA in blood of high-risk lung cancer individuals and methylation conditions of three target sites in gene coding and non-coding areas, and early diagnosis of the lung cancer is aided. The methylation-specific PCR / MSP detection method is simple and convenient in operation and low in time consumption, and the results are easily analyzed.

The invention relates to a kit for SNP genotyping of Chinese children short stature susceptibilty genes and a utilization method of the kit and particularly discloses a simultaneous qualitative and genotyping kit aiming at 12 SNP loci of 8 short stature susceptibilty genes of Chinese children and a utilization method of the simultaneous qualitative and genotyping kit. The method includes: taking a rs17038182 locus of an SPAG17 gene, a rs1378850 locus of a KBTBD gene, a rs1812175 locus of an HHIP gene, a rs10946808 locus of an HIST1H1D gene, a rs8041863 locus of an ACAN gene, a rs6182 locus of a GHR gene, a rs6184 locus of the GHR gene, a rs4410646 locus of the GHR gene, a rs12515480 locus of the GHR gene, a rs2940913 locus of the GHR gene, a rs1976667 locus of an IGF-1R gene and a rs3099 locus of an IHH gene as detection objects, respectively designing amplification primers and extension primers aiming at mutation of each SNP locus, performing multiplex PCR amplification and mark extension aiming at the 12 SNP loci, and performing capillary electrophoresis analysis to obtain genotypes of the 12 SNP loci at the same time. The kit for SNP genotyping has the advantages of convenience in use, simplicity in operation, low cost, high flux, directness and reliability of detection results and applicability to large-scale screening of SNP genotyping of the Chinese children short stature susceptibilty genes.

The present invention relates to the technical field of daily necessities design, in particular to a new type of drying device. The present invention adopts the following technical scheme: a new type of drying device, comprising a main body of the drying device, a first telescopic rod, a second telescopic rod, and a clothes drying rod 1. A quilt drying rod, the second telescopic rod can be retracted into the first telescopic rod, and an auxiliary fixing clip is arranged next to the first telescopic rod, which is characterized in that: an ultraviolet lamp is arranged in the middle of the main body of the drying device. There are drying devices at both ends, and the two ends of the clothes-drying rod are connected with the quilt-drying rod through the limit piece. The advantages of the present invention are: beautiful structure, simple operation, one-key operation of various functions, and the drying device is installed indoors, avoiding The clothes are stained with dust, and at the same time, it can prevent the clothes from falling from the balcony and hitting the passing pedestrians. Even in cloudy days, it can ensure the drying and anti-virus of the clothes. The automatic lifting mode is convenient for the elderly or special people with short stature.

The present invention presents the use of human Growth Hormone for the manufacture of a medicament for the treatment of abnormal short stature, said short stature being characterized by a Gs protein pathway dysfunction. The invention further present diagnostic methods and diagnostic kits for the determination of Gs pathway dysfunction.

Disclosed are a gonadotropin releasing hormone receptor antagonist and a pharmaceutical composition including the same, which can be useful in preventing or treating a sex hormone-related disease such as endometriosis, amenorrhea, irregular menstruation, uterine myoma, uterine fibroids, polycystic ovarian disease, lupus erythematous, hypertrichosis, precocious puberty, short stature, acne, alopecia, gonadal steroid-dependent neoplasms, gonadotropin-producing pituitary adenoma, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hyperplasia, contraception, and infertility, as well as Alzheimer disease.

The present invention relates to conjugates of biocompatible polymers and hGH, particularly PEG-hGH, where the activated biocompatible polymer is conjugated to a carboxyl group of hGH at a molar ratio of 2:1 or less, preferably 1:1, methods of preparation, and related pharmaceutical compositions. The PEG-hGH conjugates have up to 20% of the activity of the native hGH while the in vivo half life is increased 10 fold. The PEG-hGH conjugates may be used therapeutically to treat growth retardation or growth failure, especially short stature in children, and conditions related to aging.

The present invention relates to conjugates of biocompatible polymers and hGH, particularly PEG-hGH, where the activated biocompatible polymer is conjugated to a carboxyl group of hGH at a molar ratio of 1:1, methods of preparation, and related pharmaceutical compositions. The PEG-hGH conjugates have up to 20% of the activity of the native hGH while the in vivo half life is increased 10 fold. The PEG-hGH conjugates may be used therapeutically to treat growth retardation or growth failure, especially short stature in children, and conditions related to aging.

The invention provides methods for identifying an infant or child predisposed to develop symptoms of short stature, or an adult capable of genetically transmitting a predisposition to develop short stature to an offspring. The methods comprise analysis of a region of DNA in the genome of a subject located at or near a site called FRAXG on Xp22.1. In one embodiment, the analysis comprises determining the number of (CGG)n / (CCG)n nucleotide triplets within FRAXG. In another embodiment, the analysis comprises determining whether there is hypermethylation within the CpG island encompassing FRAXG. The invention also comprises probes and primers for use in the above analyses, kits containing the probes and / or primers for performing the analyses, and cell lines containing high numbers of (CGG)n / (CCG)n nucleotide triplets within FRAXG.

This invention relates to methods for predicting the magnitude of a subject's therapeutic response to agents that act on the growth hormone receptor. Preferred aspects include methods for increasing the height of human subjects having short stature, and for treating obesity and acromegaly.

Feet Extensions are improved version of custom height shoes for leg syndrome. Leg length discrepancy & Short stature. Feet Extensions are worn over the feet to add height in short leg. Unlike traditional shoes, feet extensions can be worn in shower, bathtub, and swimming pool. User can sleep in bed with feet extensions on their feet. Feet Extensions are made of silicone rubber in skin tone. Feet Extensions look more natural shape matching user feet.Feet Extensions—A device worn over the feet to add height in short leg or both legs comprising: one piece flexible silicone / rubber hollow inside; thick at the bottom; Generally human feet shaped with five open holes in front hollow inside; hole at top for feet to slide in; in human skin color tone; raised circular set of lines (2 small in front bottom part and 1 big bottom at heel) for traction for wet locations.Invention is used for: Feet Extensions are used to add height in short leg syndrome, Leg length discrepancy & Short stature.How it works: User slide feet inside Feet extension like traditional shoe. User wears them over the feet, adding height in one leg or both legs. User can wear traditional shoes over the feet extensions as feet extensions are very thin yet strong and flexible.

The invention provides a multifunctional toy stilt, which solves the problems in the prior art that the conventional stilt has higher risk and has single function, and the like. The multifunctional toy stilt comprises stilt bodies, wherein the stilt bodies are hollow; solid stilt feet are arranged at the tail ends of the bottoms of the stilt bodies; the solid stilt feet are in screw connection with the stilt bodies; and horizontal pedals are fixed on the side walls of the stilt bodies close to the joints of the stilt bodies and the solid stilt feet. The multifunctional toy stilt has the benefits as follows: the pedals of the stilt are lower and are suitable for being used by children with short statures, the risk is lower, and the children are not easy to hurt; the stilt achieves various functions and can be used as a broom or a mop or a dustpan or a writing brush or a roller brush; moreover, the multifunctional toy stilt is convenient to dismount and mount, is full of interest and entertainment, and is popular with children.

The invention relates to a single nucleotide polymorphism (SNP) marker related to Chinese horse short stature characters. The SNP molecular marker is located at the 501th position of the sequence shown in SEQ ID NO.1, polymorphism is G / A, and the SNP molecular marker corresponds to the 18205998th base pair on the eighth chromosome of a horse. The single nucleotide polymorphism (SNP) marker relatedto the Chinese horse short stature characters and application thereof have the following advantages that (1) the molecular marker is not restricted by the age, sex and the like of Chinese horses, canbe used in early breeding of the Chinese horses, accurate screening can be even performed at birth, and the breeding process of the Chinese horse superior pony varieties can be significantly promoted; (2) a method for detecting mononucleotide polymorphism of a Chinese horse TBX3 gene is accurate and reliable, and operation is simple and convenient; and (3) detection of a SNP locus of the Chinesehorse TBX3 gene provides scientific basis for Chinese horse height size marker assisted selection and horse breeding.

The invention relates to an automobile safety belt with a limiting stopper and a using method of the safety belt. According to the automobile safety belt, a first safety belt and a second safety belt which are fixed an automobile body and are retractable are fixed on the back surface of the automobile seat; a retractor I at the upper end of the safety belt is fixed on the shoulder of a driver seat; a second socket is fixed on the automobile seat; a first plug is inserted into the first socket; the second plug of the second safety belt is inserted into the second socket; the woven belts form an X-shaped cross structure; a limiting stopper is arranged above the X-shaped cross of the two woven belts; the two woven belts are respectively and sequentially arranged in two openings formed in two end surfaces of the limiting block in a sleeving manner; the transmission shaft directions on two sides of the limiting block are respectively lifted into two U-shaped grooves; the transmission shaft body is hooked by the hook ends of two locking springs; and the transmission shaft is locked in the U-shaped grooves. The automobile safety belt has the effects that according to the X-shaped cross structure of the safety belt, the safety protection of passengers is improved. The limiting stopper is increased on the chest of each passenger, the distance between two safety belts on the shoulders of the passenger can be adjusted, and the safety belt is particularly suitable for riders of short statures.

The invention discloses a method for heightening short stature, and aims at providing a method for heightening short stature which has the advantages of convenient use, safety, low cost, wide scope of application and non-treatment purpose. The key point of the technical proposal of the method lies in sleeping posture; the method is adopted to relieve physical fatigue of body caused by sleeping posture. The method is suitable for impubic persons with short stature not resulting from diseases, and the method is used for a 'non-treatment purpose'.

The invention discloses liquid traditional Chinese medicine for a regulating growth promotion function of hypothalamus-pituitary, and a preparation method of the liquid traditional Chinese medicine. The liquid traditional Chinese medicine for the regulating growth promotion function of the hypothalamus-pituitary is prepared from the following raw materials by a component ratio: 7-17 parts of prepared tortoise shell, 4-14 parts of cortex phellodendi, 4-14 parts of rhizoma anemarrhenae, 4-14 parts of cortex moutan, 7-17 parts of radix rehmanniae preparata, 7-17 parts of glue of tortoise plastron, 4-14 parts of semen cuscutae, 4-14 parts of herba epimedii, 4-14 parts of colla cornus cervi and 0.3-0.7 part of cordyceps sinensis. Compared with the prior art, the liquid traditional Chinese medicine is mainly used for treating diseases such as short stature, dietary bias, anorexia and malnutrition which are caused by endocrine disease, nanism and cretinism as well as diseases such as developmental delay type stature and short stature which are caused by genetic factor, mental factor and psychological factor. The liquid traditional Chinese medicine not only can accelerate the growth of a human body and heighten, but also can improve the memory and vision of people, promote hair growth and prevent osteoporosis.

The invention discloses a self-healing closed type piston ring mechanism, and relates to an important component, namely a piston ring technology device, of an engine frequently used in daily life andproduction of people. Aiming at the characteristics of a traditional piston ring for a short stature, a great effect, an extremely poor working environment and a high load performance requirement, bychanging structure and the installation process of the traditional piston ring, the self-healing closed type piston ring mechanism is characterized in that the self-healing closed type piston ring mechanism replaces a traditional piston ring part, relative fixation of a working position replaces a traditional movement operation, a closed piston ring replaces a traditional open type piston ring, ashort stature structure is changed into a multi-component combined giant structure, team cooperative combat replaces individual combat, the target of reinforcing various aspects of performance and functions of the traditional piston ring is achieved, and then the engine is optimized.

The present invention provides a composition comprising an indirubin derivative for stimulating longitudinal bone growth. Because the composition for stimulating longitudinal bone growth according to the present invention is shown to be effective in longitudinal bone growth, it may be used not only as a composition for stimulating longitudinal bone growth, but also as a pharmaceutical composition for treating or preventing short stature, microplasia, dwarfism, or precocious puberty.

The invention discloses an electromyography examination bed, relates to the technical field of electromyography examination beds, and solves the problem that the height of an existing examination bedis fixed, some patients with mobility problem or short stature cannot go to the bed, and once lying down, the patients is difficult to get up. The electromyography examination bed comprises a bed frame, wherein a stopper is installed on one side of the bed frame, four telescopic support rods are installed on the bottom surface of the bed frame, a motor protection shell is installed below the bed frame, crossbars are installed at both ends of the motor protection shell, a middle cushion is arranged on the upper surface of the bed frame, a hydraulic cylinder fixing plate is installed below the middle cushion, a hydraulic cylinder is installed between the hydraulic cylinder fixing plate and the bed frame, and a partition plate is installed inside the hydraulic cylinder. By installing a motorand the hydraulic cylinder, the electromyography examination bed of the invention can facilitate some patients with short stature or mobility problem to lie on the examination bed, has a simple structure and is convenient in operation.

The present invention relates to novel analogues of insulin-like growth factor-1 (IGF-1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1-receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease treatment, and cartilage repair. More particularly, the present invention relates to novel analogues of IGF-1 having an amino acid substitution at position 59, e.g., (Asn59)hIGF-1(1-70)-OH (SEQ ID NO:1), and other substitution(s) as defined herein.

The invention relates to a triangular bus pull handle with an angle adjustable function and belongs to the field of traffic. The triangular bus pull handle comprises a buckling piece which is vertically buckled, a square box with the uncovered front side is fixedly connected to the lower side of the buckling piece, and a cover plate is mounted on the front side of the square box. The interior of the square box is divided into an upper-layer space and a lower-layer space by a partition plate, and belt-penetrating holes are formed in the partition plate and the bottom of the square box correspondingly. A gear motor fixed to the rear wall of the square box through a fixing belt is mounted in the upper-layer space, and a storage wheel is mounted on a motor shaft of the gear motor. A rope beltis wound on the storage wheel, and the rear end of the rope belt penetrates through the belt-penetrating holes, stretches out of the square box and is connected to the pull handle. An electronic chipand a locking device are arranged in the lower-layer space, and the locking device is mounted over the belt-penetrating holes. A belt-penetrating hole is also formed in the middle of the locking device, and a belt-penetrating opening is formed in the upper side of the pull handle. The rear end of the rope belt penetrates through the belt-penetrating opening, is wound by a circle and is fixed through a locking buckle. The pull handle height is electrically adjusted freely, the pull handle can be automatically lowered to the lowest place, people with the short stature can touch the pull handle advantageously, the triangular bus pull handle is simple and easy to learn, and the practical effect is good.

An improved assay for measuring the release of endogenous growth hormone (GH) is described. The method focuses on determining the presence of an immediate release pool (IRP) of GH, and the extent to which it is rapidly discharged into the circulation of humans, including children. A larger and less labile pool responds continuously to long term stimulation. The method considers that determining the ten minute AUC measurement, i.e., ten minutes after induction of GH release by administering growth hormone releasing hormone (GHRH) will reveal an immediate release pool of GH. As further disclosed herein, the IRP of GH has a higher correlation with peak GH release than the conventional 120 minute time point. Further the AUC10 correlates with height standard deviation measurements whereas the AUC120 does not.

The invention relates to a blocking-preventing pedestal pan. The pedestal pan comprises a base, a cover plate, a basin body, a rotating cutter and a pedal assembly. A first clamping groove is formed in the periphery of an upper opening in the base, a second clamping groove and a third clamping groove are formed in the periphery of a lower opening in the cover plate, the first clamping groove and the second clamping groove are connected in a buckled mode, the basin body is arranged inside the base, and a fourth clamping groove is formed in the periphery of an upper opening in the basin body and connected with the third clamping groove in a buckled mode. The rotating cutter is arranged at the connecting position of the basin body and a drain pipe, the pedal assembly comprises a pedal, a rotating shaft, a fixing rod and an unlocking component, the rotating shaft is fixedly connected with the front end of the base in the transverse direction, and the fixing rod is fixedly connected with the front end of the base in the longitudinal direction. When the pedestal pan is cleaned, all the components can be separately cleaned without dead corners, and a child or a user of short stature uses the pedestal pan conveniently. In addition, the rotating cutter is arranged at the connecting position of the basin body and the drain pipe, and in this way, when flushing is performed, the rotating cutter is started to prevent blocking of the pedestal pan.

The present invention provides a composition comprising an indirubin derivative for stimulating longitudinal bone growth. Because the composition for stimulating longitudinal bone growth according to the present invention is shown to be effective in longitudinal bone growth, it may be used not only as a composition for stimulating longitudinal bone growth, but also as a pharmaceutical composition for treating or preventing short stature, microplasia, dwarfism, or precocious puberty.