The invention discloses an adjustable duplexer based on folded open-loop resonators. The adjustable duplexer comprises an upper microstrip structure layer, a middle dielectric plate layer and a lower grounding metal layer, wherein the upper microstrip structure layer comprises three input/output feeder lines, three blocking capacitors, a pair of first channel adjustable open-loop resonators and a pair of second channel adjustable open-loop resonators. Each adjustable open-loop resonator is composed of a folded microstrip line, a termination varactor diode, a center-loaded capacitor and a resistor, wherein the termination varactor diode is used for adjusting the center frequency of each channel; and the center-loaded capacitor and the resistor are used for restraining the harmonic component of each channel. A first input port and a second output port form a first channel transmission path, the first input port and a third output port form a second channel transmission path, and the two channels are mutually little influenced. The adjustable duplexer has the advantages that the center frequency of each channel is independently adjustable, the isolation degree is high, the structure is simply designed, the electric performance is good, and circuit integration and system packaging can be realized easily.