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42 results about "Quantitative analysis (chemistry)" patented technology
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In analytical chemistry, quantitative analysis is the determination of the absolute or relative abundance (often expressed as a concentration) of one, several or all particular substance(s) present in a sample.
Method for rapidly detecting bisphenol A and bisphenol AF in food
The invention relates to a method for detecting bisphenol A and bisphenol AF in food, belonging to technical field of analytical chemistry determination method. With ionic liquid (1-butyl-3-methylimidazole hexafluorophosphate) as an extractant and TritonX-100 or acetone as an dispersant, ultrasonic oscillation is carried out to form emulsion; after centrifugal separation, extraction drops at the lower layer are directly subjected to HPLC (high performance liquid chromatography) quantitative analysis. The method disclosed by the invention has the advantages of simpleness in detection steps, easiness in operation, low detection limit and high enrichment multiple, greatly reduced detection cost. The method disclosed by the invention is a rapid, efficient and environmentally friendly pre-treatment technology and has a wider application prospect in the field of food analysis.
Owner:KUNMING UNIV OF SCI & TECH TECH IND SALES MANAGEMENT
Coumarin-oxacalix[3]arene fluorescent reagents as well as preparation method and application thereof
InactiveCN103435603AConformation variableEasy to retouchOrganic chemistryFluorescence/phosphorescenceOrganic synthesisEthyl group
The invention discloses coumarin-oxacalix[3]arene fluorescent reagents as well as a preparation method and application thereof, and belongs to the fields of organic synthesis and analytical chemistry. The invention respectively synthesizes two coumarin-oxacalix[3]arene fluorescent reagents: chemical name a: 7,15,23-tertiary butyl-25,26,27-tri{1-[N-(7-coumarin oxyethyl)-1,2,3-triazole]-4-methoxy}-3,11,19-trioxacalix[3]arene; b: 7,15,23-triethoxycarbonyl -25,26,27-tri{1-[N-(7-coumarin oxyethyl)-1,2,3-triazole]-4-methoxy}-3,11,19-trioxacalix[3]arene. Meanwhile, the invention discloses a synthesis method and process conditions. According to the invention, the two coumarin-oxacalix[3]arene fluorescent reagents, in detecting ferric ions, have characteristics of high selectivity and high sensitivity; the fluorescent reagents are applicable to qualitative and quantitative analysis.
![Coumarin-oxacalix[3]arene fluorescent reagents as well as preparation method and application thereof](https://images-eureka.patsnap.com/patent_img/e78a47b1-2e36-4e56-a201-f23b2c02df82/797226DEST_PATH_IMAGE012.png "Coumarin-oxacalix[3]arene fluorescent reagents as well as preparation method and application thereof")
![Coumarin-oxacalix[3]arene fluorescent reagents as well as preparation method and application thereof](https://images-eureka.patsnap.com/patent_img/e78a47b1-2e36-4e56-a201-f23b2c02df82/995070DEST_PATH_IMAGE007.png "Coumarin-oxacalix[3]arene fluorescent reagents as well as preparation method and application thereof")
![Coumarin-oxacalix[3]arene fluorescent reagents as well as preparation method and application thereof](https://images-eureka.patsnap.com/patent_img/e78a47b1-2e36-4e56-a201-f23b2c02df82/130822154350.png "Coumarin-oxacalix[3]arene fluorescent reagents as well as preparation method and application thereof")
Owner:GUIZHOU UNIV
Quantitative analysis method of vanadium in high chrome alloy
InactiveCN101413898AEliminate distractionsSimple and fast operationMaterial analysis by observing effect on chemical indicatorMasking agentMaterials science
The invention relates to a method used for quantitative analysis on vanadium in high-chromium alloy, in particular to the method used for the quantitative analysis on vanadium in hydrogen storage alloy, belonging to the analytical chemistry field. The technical problem to be solved is that the interference of vanadium is eliminated and the content of the vanadium in the high-chromium alloy is exactly and quantitatively analyzed. The analysis method adopts solution mixed by sulfuric acid, nitric acid and hydrochloric acid to dissolve the high-chromium alloy, then takes ethanol as a masking agent and uses ammonium ferrous sulfate to carry out titration analysis on the content of the vanadium; wherein, the proportion of the mixed solution of sulfuric acid, nitric acid, hydrochloric acid and water is 4-6:2-3:4-6:10-15. The analysis method has simple and convenient operation, is easy to be handled, eliminates the chromium interference, enlarges the applicable range of the existing method used for measuring the content of vanadium by the ammonium ferrous sulfate volumetric method, and provides a new method for quantitatively analyzing the content of the vanadium in the high-chromium alloy, especially in the hydrogen storage alloy.
Owner:PANZHIHUA UNIV
Preparation method and application of ratiometric fluorescent probe for detecting hydrazine
ActiveCN108982447AReduce consumptionImprove detection accuracyOrganic chemistryColor/spectral properties measurementsCyclohexanoneSodium acetate
The invention relates to a preparation method and application of a ratiometric fluorescent probe for detecting hydrazine. The preparation comprises the steps that phosphorus oxychloride is dissolved in dichloromethane, the mixture is slowly dropped into N,N-dimethylformamide, and after the dropwise addition is finished, cyclohexanone is added for reaction so as to obtain a compound 1; then, benzoindoles and iodoethane are dissolved in acetonitrile for heating and refluxing reaction so as to obtain a compound 2; the compound 1 and the compound 2 are subjected to heating and refluxing by takingmethylbenzene and n-butyl alcohol as solvents so as to obtain a fluorescent probe compound 3; the compound 3 is dissolved in anhydrous N,N-dimethylformamide, and sodium acetate is added for reaction under the protection condition of nitrogen so as to generate a compound 4; and the compound 4 is dissolved in anhydrous dichloromethane containing acetyl chloride, triethylamine is added for reaction for 4 hours at normal temperature under the protection of the nitrogen so as to generate the probe Ben-Cy1. ccording to the preparation method and application of the ratiometric fluorescent probe, theprobe works in a near-infrared region, is suitable for qualitative and quantitative analysis, low biotoxicity and high selectivity in biological samples and can be applied to the related fields of analytical chemistry, life organic analytical chemistry and the like.
Owner:QUFU NORMAL UNIV
Quantitative analysis method for judging a petroleum degradation grade
The invention relates to the technical field of oil gas geochemistry, in particular to a quantitative analysis method for judging petroleum degradation grade. The quantitative analysis method comprises the following steps: a sample preparation step of dehydrating a water-containing degraded oil sample and then weighing 50-100mg of the dehydrated water-containing degraded oil sample in a sample bottle; a sample degradation grade quantitative analysis step of analyzing the sample by using comprehensive two-dimensional gas chromatography-time of flight mass spectrometry; calculating the relativemass of n-isoparaffin, cyclane, arene and sterane, and terpane compound according to a peak area of a comprehensive two-dimensional gas chromatogram to be respectively denoted as A, B, C, D, and calculating an X value, wherein X=A / (A+B+C+D), the smaller the X value is, the larger the degradation grade is. The quantitative analysis method of the invention can finely divide the crude oil with the same source and the same degradation grade, thereby classifying the crude oil for geological research.
Owner:CHINA PETROLEUM & CHEM CORP +1
Analytical method of glucosamine
InactiveCN101271093AReduce mistakesQuick analysisComponent separationAnalysis methodCHEMISTRY METHODS
The invention pertains to the field of analytical chemistry, in particular to a high-performance liquid chromatography analysis method of glucosamine. The implementation of the invention completely establishes a high-efficient, rapid, accurate and precise quantitative analysis method of the glucosamine, thus building a good foundation for the application and the detection of the glucosamine in foods, health foods and drugs.
Owner:BEIJING TRADE STAR MEDICAL TECH
Dual-template molecule amino functionalized metal organic framework imprinted polymer as well as synthesis method and application thereof
ActiveCN111471147ARapid Adsorption Equilibrium CapabilityHigh sensitivityOther chemical processesGlycidyl methacrylateFunctional monomer
The invention belongs to the field of analytical chemistry, and discloses a dual-template molecule amino functionalized metal organic framework imprinted polymer. MIL-101(Cr)-NH2 is adopted as a carrier, double bonds of a functional monomer that is glycidyl methacrylate are modified to the carrier, then a precipitation polymerization reaction is carried out under the initiation of an initiator through the cross-linking action of a cross-linking agent, and the surface molecularly imprinted polymer is synthesized on the periphery of the carrier in a chemical bond grafting mode. By combining thesynthesized CPT-MIPs with an SPE technology, a solid-phase extraction small column is self-made and is applied to separation and enrichment pretreatment of zearalenone and aflatoxin in grains. Practical application shows that the disclosed polymer is high in sensitivity, high in precision, low in detection limit and quantification limit, good in recovery effect and stable in recovery rate. The method is stable and reliable, and can be used for quantitative analysis of actual samples. The CPT-MIPs column can be regenerated through elution and can be repeatedly used.
Owner:HENAN VOCATIONAL COLLEGE OF WATER CONSERVANCY ANDENVIRONMENT +1
GC-MS (Gas Chromatography-Mass Spectrometer) analysis method for quantitatively analyzing polycyclic aromatic hydrocarbon in aquatic product
InactiveCN107102074ALow detection limitHigh precisionComponent separationGas phaseMass chromatography
The invention relates to a polycyclic aromatic hydrocarbonanalytical test method in the field of analytical chemistry, and concretely relates to a gas chromatography-mass spectrometry method applicable to quantitatively analyzing polycyclic aromatic hydrocarbon in an aquatic product. Aiming at a complex matrix of an animal-origin (aquatic product) food rich in fat, protein and macromolecular substances, the method comprises the steps of utilizing gel permeation chromatography for degreasing, then utilizing an aluminium oxide-silica gel compound chromatography purification column for effectively extracting the polycyclic aromatic hydrocarbon, utilizing gas chromatography and mass spectrometry for carrying out quantitative analysis, and building the GC-MS (Gas Chromatography-Mass Spectrometer) analysis method for quantitatively analyzing the polycyclic aromatic hydrocarbon in the aquatic product. Compared with an existing method, the method provided by the invention is higher in target compound recovery rate, beneficial for removing matrix interference, improving detection limit and reducing detection cost, and applicable to aquatic product safety evaluation, and the like.
Owner:贵阳市环境信息中心
Method for performing accurate quantitative analysis on metal elements
ActiveCN110132916AReduce consumptionReduce system errorPreparing sample for investigationMaterial analysis by electric/magnetic meansQuantification methodsStandard methods
The invention relates to the field of analytical chemistry, in particular to a method for performing accurate quantitative analysis on metal elements by a patent technology combining a standard addition method and a differential method during accurate quantification. According to the analysis method, the standard addition method and the differential method are combined; a standard curve concentration calculation formula based on the differential method is designed; in combination with software calculation, a standard curve is established by using the standard addition method; the efficiency ofpreparing the standard curve is improved; and the interference caused by the matrix effect is effectively reduced, so that accurate quantification of the metal elements is realized. According to themethod, the calculated amount of preparing the standard curve by using the traditional standard addition method is greatly reduced, so that the quantitative analysis precision and speed of the harmfulmetal elements are improved; the standard addition method can replace the standard curve method (an external standard method); the accurate quantification method for the metal elements can be appliedto the detection of batch samples; and the method serves as a method for efficiently measuring the element concentration when a used instrument measures a special device without using the standard addition method.
Owner:李蒙
Detection method for polychlorinated naphthalene content in electronic and electrical product rubber part
ActiveCN102359994AAccurate measurementEfficient removalComponent separationElectron capture detectorGas liquid chromatographic
The present invention discloses a detection method for a polychlorinated naphthalene content in an electronic and electrical product rubber part. The method comprises the following steps: (1) crushing an electronic and electrical rubber sample to obtain a homogeneous sample; (2) adding heavy metal powder to the crushed sample, adopting an accelerated solvent extraction method to completely extract the polychlorinated naphthalene in the sample, taking the extracting solution; (3) completely transferring the extracting solution to a solid phase extraction column, adopting a mixed solvent to carry out elution, and collecting and concentrating the eluent to obtain the purified extracting solution; (4) preparing a mixed standard solution, loading the purified extracting solution and the prepared mixed standard solution on a gas chromatograph to carry out detection, adopting an electron capture detector to collect the signal, adopting a chemistry station to carry out data processing and quantitative analysis to obtain the polychlorinated naphthalene content in the electronic and electrical product rubber part. With the method of the present invention, the impurities with interference in the rubber can be effectively removed, the polychlorinated naphthalene can be completely extracted, the purification degree is high, the detection sensitivity is high and the detection cost is low.
Owner:广东德威检验认证有限公司
Preparation method and application of multifunctional super-sensitive Zn<2+> two-photon detection fluorescence molecular probe
ActiveCN108299402AImprove accuracyStrong specificityOrganic chemistryFluorescence/phosphorescenceOsmium tetroxideDisease
The invention relates to a preparation method and application of a multifunctional super-sensitive Zn<2+> two-photon detection fluorescence molecular probe. Firstly, 2,4-dihydroxy benzaldehyde, diethyl glutaconate and anhydrous piperidine react in ethanol to obtain a product 1; the product 1 and acetic anhydride react in anhydrous pyridine to obtain a product 2; the product 2, osmium tetroxide andsodium periodate react in tetrahydrofuran to obtain a product 3; the product 3 and anhydrous potassium carbonate react in methyl alcohol to obtain a product 4; finally, the product 4 id dissolved into the ethanol; 2-hydrazinopyridine and glacial acetic acid are added; the steps of backflow, recrystallization and the like are performed; the multifunctional super-sensitive Zn<2+> two-photon detection fluorescence molecular probe is obtained. The probe is applicable to the qualitative and quantitative analysis of Zn<2+> in a biological sample; the detection is sensitive, accurate and fast; the probe can be applied to the relevant fields of analytical chemistry, life organic analytical chemistry, disease advanced diagnosis, medical clinic detection and the like.
Owner:QUFU NORMAL UNIV
Application of computer in quantitative analysis chemistry experiment
InactiveCN103514575ATimely monitoring accuracyReal-time monitoring precisionData processing applicationsMathematical modelOperability
The invention discloses an application of a computer in a quantitative analysis chemistry experiment. According to experiment schemes of 19 experiment items of the quantitative analysis chemistry experiment, a mathematic model is written, according to the mathematic model, the computer language is used for carrying out programming on the mathematic model; a compiled computer program can automatically process experiment data, absolute errors, relative errors and the like are computed automatically; the computer can automatically evaluate the experiment performance of students according to the computing results of the experiment data and relevant relative errors; the computer automatically signs the correcting date; the computer automatically prints lab report books of the students; the computer automatically stores the experiment performance of the students and the lab report books of the students; timely calling can be achieved, so that calling during teaching quality evaluation and teaching quality inspection in the future is convenient. According to the application, the experiment content is wide in selecting face, representativeness is strong, practicability is strong, pertinence is strong, and systematicness and operability are strong.
Owner:LANZHOU CITY UNIV
Method for rapidly detecting bisphenol A and bisphenol AF in food
Owner:KUNMING UNIV OF SCI & TECH TECH IND SALES MANAGEMENT
Method for determining content of residual methylsiloxane in organosilicon softener by using HS-GC external standard method
PendingCN111929384AEnable accurate testingHigh precisionComponent separationGas liquid chromatographicOrganosolv
The invention belongs to the technical field of analytical chemistry, and particularly relates to a method for determining the content of residual methylsiloxane in an organosilicon softener by usingan HS-GC external standard method. A headspace gas chromatograph is used for detection, and an external standard method is used for quantitative analysis. The gas chromatograph is an Agilent gas chromatograph 7890B, the gas chromatographic analysis conditions are as follows: a chromatographic column is DB-1701 or a chromatographic column with equivalent polarity, the column length is 30m, the column inner diameter is 320 microns, the initial column temperature is 100 DEG C, the temperature is kept for 2 minutes, then the temperature is increased to 260 DEG C at the rate of 10 DEG C / min, the temperature is kept for 10 minutes, and the carrier gas flow rate is 3mL / min. The method has the advantages of high precision, good reproducibility, no need of any solvent extraction pretreatment operation on the sample, reduction of the use amount of the organic solvent, shortening of the analysis time, and simplicity and safety.
Owner:ZIBO LURUI FINE CHEM CO LTD
Detection method of glucosinolate compounds
ActiveCN113391001AHigh sensitivityGuaranteed detection sensitivityComponent separationChemical physicsThio-
The invention belongs to the technical field of analytical chemistry, and provides a detection method of glucosinolate compounds. According to the method, common secondary mass spectrum fragments of glucosinolate compounds are adopted, so that the purpose of high-efficiency qualitative analysis is achieved; in the secondary mass spectrum fragments, a set of precursor ion mode scanning qualitative method is constructed based on the fragments with m / z of 96.0, so that the detection sensitivity can be ensured, the qualitative accuracy can be improved, and false positive detection results are reduced; on the basis that the fragments with the m / z of 96.0 are used as quantitative ions, a set of multi-reaction monitoring (MRM) mode scanning quantitative method is constructed by utilizing glucosinolate compound standard substances, quantitative analysis of all glucosinolate compounds in a sample is completed, the problem that quantitative analysis cannot be achieved due to the fact that some standard substances are difficult to obtain is solved, and individual quantification and total amount determination of the compounds in the sample are efficiently completed.
Owner:SHANGHAI ACAD OF AGRI SCI
Substituted pyrimidine type compound as well as preparation method and use thereof
The invention belongs to the medical chemistry field and particularly relates to a substituted pyrimidine type compound, a preparation method thereof and use thereof as a reference substance for the qualitative and / or quantitative analysis of relevant impurities in quality research of a raw material drug of mesylate of (S)-4-amino-6-((1-(8-chloro-4-oxo-2-phenyl-1,4-dihydroquinolin-3-yl)ethyl)amino)pyrimidine-5-cyano.
Owner:NANJING SANHOME PHARMACEUTICAL CO LTD
Preparation method and application of a ratiometric fluorescent probe for detecting hydrazine
ActiveCN108982447BReduce consumptionImprove detection accuracyOrganic chemistryColor/spectral properties measurementsCyclohexanoneSodium acetate
The invention relates to a preparation method and application of a ratiometric fluorescent probe for detecting hydrazine. The preparation comprises the steps that phosphorus oxychloride is dissolved in dichloromethane, the mixture is slowly dropped into N,N-dimethylformamide, and after the dropwise addition is finished, cyclohexanone is added for reaction so as to obtain a compound 1; then, benzoindoles and iodoethane are dissolved in acetonitrile for heating and refluxing reaction so as to obtain a compound 2; the compound 1 and the compound 2 are subjected to heating and refluxing by takingmethylbenzene and n-butyl alcohol as solvents so as to obtain a fluorescent probe compound 3; the compound 3 is dissolved in anhydrous N,N-dimethylformamide, and sodium acetate is added for reaction under the protection condition of nitrogen so as to generate a compound 4; and the compound 4 is dissolved in anhydrous dichloromethane containing acetyl chloride, triethylamine is added for reaction for 4 hours at normal temperature under the protection of the nitrogen so as to generate the probe Ben-Cy1. ccording to the preparation method and application of the ratiometric fluorescent probe, theprobe works in a near-infrared region, is suitable for qualitative and quantitative analysis, low biotoxicity and high selectivity in biological samples and can be applied to the related fields of analytical chemistry, life organic analytical chemistry and the like.
Owner:QUFU NORMAL UNIV
Method for using HS-GC (headspace gas chromatography) external standard method to measure residual acrylic acid in acrylic polymer
The invention belongs to the technical field of analytical chemistry, and particularly relates to a method for using an HS-GC (headspace gas chromatography) external standard method to measure the residual acrylic acid in a acrylic polymer. A headspace gas chromatographic instrument is adopted to conduct detection and external standard method quantitative analysis, wherein the gas chromatographicinstrument is an Agilent gas chromatography 7890B, the gas chromatography analysis conditions are that chromatographic columns are chromatographic columns with DB-WAX or polarity being equivalent, thelength of the columns is 30 m, the inner diameter of the columns is 320 microns, the initial column temperature is 130 DEG C, the temperature is maintained for 2 minutes, then the temperature is risen to be 190 DEG C at the ratio of 20 DEG C / min, the temperature is maintained for 12 minutes, and the flow rate of carrier gas is 1 ml / min. The method is high in precision, good in reproducibility, high in accuracy and good in repeatability, can achieve direct detection of samples, avoids influences of raw materials and by-products to the product peak, shortens the analysis time, is simple and practical, and convenient and reliable.
Owner:ZIBO LURUI FINE CHEM CO LTD
Method for analyzing residual solvent in enoxaparin sodium
InactiveCN111289662AStir wellAccurate analysisComponent separationGas liquid chromatographicNitrogen gas
The invention discloses a method for analyzing a residual solvent in enoxaparin sodium. The method specifically comprises the following steps: S1, taking a capillary column, setting carrier gas of thecapillary column to be nitrogen, setting the column flow rate of the capillary column to be 3.0 ml / min, the hydrogen flow rate to be 35.0 ml / min, the air flow to be 350.0 ml / min, the tail blowing flow to be 30ml / min, the column temperature of the capillary column to be 120 DEG C, the temperature of a sample inlet to be 200 DEG C, and the split ratio to be 20: 1, using a hydrogen flame ionizationdetector as detection equipment, and setting the temperature of the detector to be 250 DEG C; and S2, carrying out sample introduction of a sample solution in a headspace sample introduction mode, andsetting the equilibrium temperature of a headspace sample injector to be 85 DEG C. The invention relates to the technical field of analytical chemistry. According to the method for analyzing the residual solvent in the enoxaparin sodium, a simple gas chromatography determination method is adopted, the residual quantity level of methanol, ethanol and dichloromethane in the enoxaparin sodium is accurately analyzed, and qualitative and quantitative analysis can be more rapidly and accurately carried out on organic solvent residues in the enoxaparin sodium.
Owner:HUBEI YINUORUI BIOLOGICAL PHARMA
Preparation method and application of a multifunctional ultrasensitive zn2+ two-photon detection fluorescent molecular probe
ActiveCN108299402BReduce consumptionImaging DiverseOrganic chemistryFluorescence/phosphorescenceOsmium tetroxideAcetic anhydride
Owner:武汉聚成医疗科技有限公司
Method for simultaneously determining various organophosphorus in vegetable oil by combining dispersive liquid-liquid microextraction with gas chromatography
ActiveCN113030362ALow limit of quantitationHigh sensitivityComponent separationVegetable oilOrganosolv
The invention discloses a method for simultaneously and rapidly determining various organophosphorus in vegetable oil by combining dispersive liquid-liquid microextraction with gas chromatography, which belongs to the field of analytical chemistry. The method specifically comprises the following steps of: (1) preparing a mixed standard solution; (2) extracting a sample; (3) carrying out dispersive liquid-liquid microextraction; (4) carrying out gas chromatographic analysis; and (5) formulating a standard working curve and performing quantitative analysis. In the detection process, a large amount of organic solvent is not needed, and the method is green, environment-friendly, rapid, efficient, high in detection result sensitivity and good in reproducibility.
Owner:SHANDONG INST FOR FOOD & DRUG CONTROL
A kind of analytical method for detecting aspartic acid ornithine impurity
The invention discloses an analysis method for detecting impurities in aspartic acid ornithine, which belongs to the field of analytical chemistry; the method adopts liquid chromatography, amino-bonded silica gel filler, Thermo APS‑2 4.6×250mm, 5 μm, and 0.1mol / L potassium dihydrogen phosphate buffer-acetonitrile (35:65) is mobile phase A, 0.1mol / L potassium dihydrogen phosphate buffer-acetonitrile (50:50) is mobile phase B; the detection wavelength is 200nm; The flow rate is 1.0ml per minute; the column temperature is 30°C, and gradient elution is used for analysis. This technical solution can quickly and accurately detect 3‑amino‑2‑piperidone and dimer arginine in impurities aspartic acid ornithine acid, α-aspartic acid dimer, and aspartic acid condensate for qualitative and quantitative analysis, and the resolution is good, the detection limit and quantification limit are low, and the linear range is wide, so that it can be calculated more accurately The content of different impurities provides technical support for further monitoring and research of impurities in ornithine-aspartate.
Owner:SHANDONG INST FOR FOOD & DRUG CONTROL
Tricyclic compound as well as preparation method and application thereof
The invention belongs to the field of medical chemistry and particularly relates to a tricyclic compound, a preparation method thereof and application thereof as a reference substance in qualitative and / or quantitative analysis of related impurities in the research of the quality of a raw material drug of N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(6,7,8,9-tetrahydropyrido [1,2-a] indol-10-yl) pyrimidine-2-yl) amino) phenyl)allylamide methanesulfonate.
Owner:NANJING SANHOME PHARMACEUTICAL CO LTD
A quantitative analysis of metalloporphyrin MOFs material co 2 /ch 4 method of separation efficiency
InactiveCN104899356BAvoid blindnessAvoid complexityAdsorption purification/separationSpecial data processing applicationsMolecular sieveQuantum chemistry
The invention discloses a method for quantitatively analyzing efficiency of metalloporphyrin MOFs materials in separating CO2 / CH4. According to the method of the invention, the efficiency of the metalloporphyrin MOFs materials in separating CO2 / CH4 is quantitatively analyzed based on density functional theory calculation of auantum chemistry and Monte Carlo molecular simulation. By determining interaction energy between probe molecules and different metalloporphyrin ligands and adsorption heat, interaction between CO2 and metalloporphyrin MOFs materials is quantitatively analyzed, and finally calculation of selectivity in adsorption of CO2 / CH4 is used to characterize efficiency and features of different metalloporphyrin MOFs materials in separating CO2 / CH4. The method comprises steps of: construction of a cluster model; structural optimization of a stable structure and calculation of partial charges; calculation of a CO2 / CH4 separation coefficient; calculation of adsorption energy and adsorption heat; and analysis and characterization of efficiency in separating CO2 / CH4. According to the method of the invention, efficiency of metalloporphyrin MOFs materials in separating CO2 / CH4 can be quantitatively characterized without any actual experiment. The method of the invention can be further extended for analysis of efficiency of other porous molecular sieves of known crystal structures and MOFs materials in separating CO2 / CH4.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Method for separating and determining rucotinib phosphate and impurities by high performance liquid chromatography
ActiveCN113820413AEfficient separationUndisturbedComponent separationBulk chemical productionFluid phasePhosphate
The invention relates to the field of analytical chemistry, and particularly discloses a method for separating and determining rucotinib phosphate and impurities by high performance liquid chromatography. According to the method, related chromatographic condition parameters are improved, so that the rucotinib phosphate and the impurities can be well separated, and qualitative and quantitative analysis is carried out on the main drug and the impurities thereof by utilizing the method. The method is good in specificity and is not interfered by a blank solvent and other unknown impurities, the separation degree between a main peak and the impurity B is 3.99, the separation degrees between other known impurities are all larger than 1.5, and the method has the advantages of being simple, rapid, high in accuracy and the like.
Owner:CHONGQING HUABANGSHENGKAI PHARM
Method for separating and determining posaconazole Z2 and impurities thereof
ActiveCN113671086AHigh recovery rateMeet control requirementsComponent separationBulk chemical productionOrganosolvGradient elution
The invention belongs to the technical field of analytical chemistry, and particularly relates to a method for separating and determining posaconazole Z2 and impurities thereof. The method comprises the following steps: carrying out gradient elution separation by using liquid chromatography, wherein a mobile phase of the liquid chromatography is a mixed solution of a mobile phase A and a mobile phase B, the mobile phase A is an ammonium acetate-formic acid-aqueous solution, and the mobile phase B is an organic solvent; and performing mass spectrometry detection by using a quadrupole mass spectrometer to realize quantitative analysis. According to the method, the detection limit reaches the extremely low concentration of 0.35 ng / ml, the control requirement of ICH can be met, the impurity limit needs to be controlled to be 2.5 ppm or below, Z2 and Z2h can be well separated, and the recovery rate of Z2h is increased to the qualified level.
Owner:CHONGQING HUAPONT PHARMA
Quinoline compound as well as preparation method and application thereof
The invention belongs to the field of medical chemistry, and particularly relates to a quinoline compound, a preparation method thereof and application of the quinoline compound as a reference substance in qualitative and / or quantitative analysis of related impurities in quality research of 4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-yl) oxy)-7-(3-(trifluoromethyl)-5, 6-dihydro-[1, 2, 4] triazolo [4, 3-a] pyrazine-7 (8H)-yl) quinoline bulk drug.
Owner:NANJING SANHOME PHARMACEUTICAL CO LTD
Detection method for polychlorinated naphthalene content in electronic and electrical product rubber part
ActiveCN102359994BAccurate measurementEfficient removalComponent separationElectron capture detectorGas liquid chromatographic
Owner:广东德威检验认证有限公司
A class of coumarin-oxaccalix[3]arene fluorescent reagents and their preparation methods and applications
InactiveCN103435603BConformation variableEasy to retouchOrganic chemistryFluorescence/phosphorescenceOrganic synthesisEthyl group
A class of coumarin-oxacalix[3]arene fluorescent reagent and its preparation and application of the present invention belong to the field of organic synthesis and analytical chemistry. The present invention synthesizes two kinds of coumarin-oxacalix[3]arene fluorescence reagents respectively Reagent, chemical name a : 7,15,23-tri-tert-butyl-25,26,27-tri{1-[N-(7-coumarinoxyethyl)-1,2,3-triazole]-4-methyl Oxy}-3,11,19-trioxacalix[3]arene; b : 7,15,23-triethoxycarbonyl-25,26,27-tri{1-[N-(7-coumarinoxyethyl)-1,2,3-triazole]-4-methanol Oxygen}-3,11,19-trioxacalix[3]arene, and discloses the synthesis method and process conditions, the present invention uses two kinds of coumarin-oxacalix[3]arene fluorescent reagents to detect three Valence iron ion, with high selectivity and high sensitivity, can be used for qualitative and quantitative analysis.
![A class of coumarin-oxaccalix[3]arene fluorescent reagents and their preparation methods and applications](https://images-eureka.patsnap.com/patent_img/3d24ba1a-9e71-4ce3-ad54-631d9415d5aa/130822154350.PNG "A class of coumarin-oxaccalix[3]arene fluorescent reagents and their preparation methods and applications")
![A class of coumarin-oxaccalix[3]arene fluorescent reagents and their preparation methods and applications](https://images-eureka.patsnap.com/patent_img/3d24ba1a-9e71-4ce3-ad54-631d9415d5aa/130822154355.PNG "A class of coumarin-oxaccalix[3]arene fluorescent reagents and their preparation methods and applications")
![A class of coumarin-oxaccalix[3]arene fluorescent reagents and their preparation methods and applications](https://images-eureka.patsnap.com/patent_img/3d24ba1a-9e71-4ce3-ad54-631d9415d5aa/130822154358.PNG "A class of coumarin-oxaccalix[3]arene fluorescent reagents and their preparation methods and applications")
Owner:GUIZHOU UNIV
Quantitative analysis of multi-components by single marker of medicine
PendingCN113945643AEasy to separateGood reproducibilityComponent separationSalvia miltiorrhizaCapsule
The invention relates to the field of analytical chemistry, in particular to a quantitative analysis of multi-components by single marker of medicine, which can be used for detecting 10 chemical components of typha angustifolia-ginseng capsules and detecting anthraquinone components in one or more extracts of codonopsis pilosula, ligusticum wallichii, red paeony root, rhizoma alismatis, salvia miltiorrhiza, hawthorn, pollen typhae and polygonum multiflorum. The method is quick, simple, convenient and accurate.
Owner:NANJING SUZHONG PHARMA RES CO LTD +1
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