The invention relates to a high-stability NTC (negative temperature coefficient) thermistor suitable for a medium-temperature zone and a preparation method of the thermistor. The thermistor comprises oxides of four metallic elements including Co, Mn, Fe and Zn, the oxides are subjected to preparation with a coprecipitation method, forming, sintering, slicing, electrodefiring, cutting and packaging, then the high-stability NTC thermistor suitable for the medium-temperature zone is obtained, the standard resistance of the thermistorat the temperature of 25 DEG C ranges from 50-180 kilohms, and the material constant ranges from 3,990 K to 4.270 K. The thermistor device has the standard resistance and material constantsuitable for the medium-temperature zone, can be applied to temperature measurement, control, compensation and the like of equipment such as an automobile, an air conditioner, a microwave oven and the like and has very good stability, consistency and interchangeability, the resistance drift rate is smaller than 0.1% after the thermistor is aged for 1,000 h at the temperature of 150 DEG C, the stability of the conventional NTC thermistor can be improved greatly, the measurement accuracy of the NTC thermistor can be improved, and the service life of the NTC thermistor can be prolonged.