The present invention provides a staring imaging simulation and quality evaluation method and device taking regard of satellite comprehensive motion, the method is as follows: according to the application requirements, load physical parameter indexes are designed; according to the satellite platform design specifications, a satellite motion trail under ideal state is simulated, and perturbation factors are corrected; according to the satellite motion trail and imaging target location, an attitude maneuver angle at the moment of satellite staring imaging can be automatically calculated, and drift angle is corrected; according to the satellite motion trail, attitude data and camera design parameters and the like, an ideal staring imaging simulation image is generated; by discretization of the exposure time, transient simulation image sequences with satellite motion errors within the exposure time can be generated, a first exposed simulation image is synthesized, an edge method is used for statistics of image MTF value, target staring imaging quality under satellite comprehensive motion can be evaluated, the staring imaging simulation and quality evaluation method achieves the target staring imaging image simulation under satellite comprehensive motion, and staring imaging image quality evaluation taking regard of satellite comprehensive motion.