The invention discloses an automatic cotton laboratory sample compression forming device. The automatic cotton laboratory sample compression forming device comprises a base, a left box plate, a right box plate, a lower box door, an upper box door, crossbeams, an oil cylinder, a guide rod and a guide wheel, wherein the left box plate and the right box plate are arranged above the base, the lower box door and the upper box door which can be opened front and back are arranged on the left box plate and the right box plate, the crossbeams are arranged on the tops of the left box plate and the right box plate, the oil cylinder and the guide rod are arranged on the crossbeams, the guide wheel is matched with the guide rod, a main pressure device is arranged on the lower part of the oil cylinder, an upper pressure head is arranged on the lower part of the main pressure device, the guide rod penetrates through the guide wheel and the crossbeam and is then connected with the main pressure device, a lower pressure head is arranged on the upper part of the base, and the upper pressure head and the lower pressure head are matched with each other; the left box plate, the right box plate, the lower box door and the upper box door form a space capable of accommodating cotton. The automatic cotton laboratory sample compression forming device is relatively simple in structure, the remaining cotton samples after the inspection can be compressed into laboratory samples with certain specification, density and shape, the cotton sample processing way is in a mechanical mode instead of a manual operation mode, the working efficiency is effectively improved, and a positive role in better preventing the fire risk can be realized.