The invention discloses a preparation method of a medicinal liquor. The medicinal liquor is composed of 400g of radix polygoni multiflori, 50g of radix angelicae sinensis, 10g of Chinese wolfberry, 30g of apricot kernel, 10g of ginger, 20g of honey, 8g of radix ophiopogonis, 3g of ginseng, 2kg of sticky rice, 10 red dates, and 2g of cortex eucommiae. The preparation method comprises following steps: 1, radix polygoni multiflori is boiled with water and mashed, and ginger is juiced; 2, radix angelicae sinensis, Chinese wolfberry, apricot kernel, radix ophiopogonis, ginseng, and red date are smashed into crude powder, and are mixed with the mashed radix polygoni multiflori, and an obtained mixture is sealed in a cloth bag; 3, sticky rice is mixed with 2500ml of water, and an obtained solution is boiled with slow fire so as to obtain a porridge, and the porridge is stored in an earthen jar; 4, the porridge is cooled, and is uniformly mixed with ginger juice, and an obtained mixed material is sealed; 5, cortex eucommiae fine powder is added into an obtained vinasse for uniform mixing, and an obtained mixed product is sealed for 4 to 6 days and then is unsealed; 6, residue is removed, an obtained product is stored in the earth jar, and the cloth bag obtained in step 2 is added into obtained liquor; 7, the earth jar is subjected to water bath for 1.5h, and then is buried in soil; 8, 5 days later, the earth jar is unburied, the cloth bag is removed, and honey is added into the liquor. The medicinal liquor is heated to be warm, and 15 to 20ml is drunk with an empty belly twice a day.