The invention discloses an intelligent microneedle puncture instrument, a network system and a control method. The intelligent microneedle puncture instrument comprises a hollow cylindrical shell, a control mechanism, a driving mechanism, a flexible needle outlet adjusting mechanism and a microneedle suite, wherein the control mechanism, the driving mechanism and the flexible needle outlet adjusting mechanism are sequentially arranged in a hollow cavity of the shell from top to bottom, and the microneedle suite is detachably connected with the flexible needle outlet adjusting mechanism; and the microneedle array obtains needle withdrawing and puncturing depth ranges of 0-(H1 + H2) in the axial direction, makes contact with the skin of each area and punctures the skin, and transdermal drug delivery or physical therapy is carried out. The network system comprises an intelligent microneedle puncture instrument and an intelligent terminal, and the intelligent terminal is provided with a beauty/physiotherapy control applet or APP. The control method comprises the steps that the intelligent microneedle puncture instrument, an intelligent mobile phone and a remote server are connected, the APP calls the intelligent terminal, data of a user is obtained, the intelligent puncture instrument is controlled to work, and transdermal drug delivery or physiotherapy of the skin is carried out. The intelligent microneedle puncture instrument is easy to use, large in puncture depth adjusting range, good in effect and high in safety.