The invention discloses an energy-saving comprehensive plant management and control system based on photovoltaic power generation. The system comprises a master control module, a photovoltaic power generation and mains output module, a dust data acquisition module, an environmental data acquisition module, an electrical parameter acquisition module, a storage module, a display alarm module, an indoor environment adjustment module, a dust adjustment module, a wireless communication module and a mobile receiving control terminal. The comprehensive control system can monitor dust concentration, harmful gas concentration, microbial concentration, negative ion concentration and temperature and humidity information in a plant in real time, and can automatically control dust concentration and environmental parameters in a workshop as needed; meanwhile, the system is powered through combination of photovoltaic power generation technology and mains, light energy is converted into required power energy, energy pressure is relieved, pollution is reduced, and energy saving and environmental protection effects are achieved; besides, a standby power supply can be provided after power failure, the anti-risk property of the system is improved, and broad application prospect is realized.