The invention belongs to the technical field related to inkjet printing, and specifically discloses an inkjet printing multi-nozzle ink path air pressure control system and its application, which includes a positive pressure generation and adjustment unit, a negative pressure generation and adjustment unit, an ink path and a nozzle unit And the air circuit and ink circuit control unit, the positive pressure generation and adjustment unit and the negative pressure generation and adjustment unit are respectively connected with the ink circuit and the nozzle unit, and are used to provide positive pressure gas and negative pressure gas for the ink circuit and the nozzle unit , the gas circuit and the ink circuit control unit are respectively connected with the positive pressure generation and adjustment unit, the negative pressure generation and adjustment unit, the ink circuit and the nozzle unit, and are used to coordinate and control these three units to pass the positive and negative pressure gas The control realizes high-precision inkjet printing. The invention can realize functions such as ink supply and pressure of ink or solution in the ink path, jet printing, low-frequency jet, nozzle cleaning, ink recovery, etc., and has the advantages of compact structure, stable pressure, easy manipulation, high precision and high degree of automation.