The invention relates to an acceleration sensor, in particular to a piezoresistive MEMS high-range acceleration sensor with no lead and a manufacturing method of the piezoresistive MEMS high-range acceleration sensor with no lead. The piezoresistive MEMS high-range acceleration sensor with no lead and the manufacturing method of the piezoresistive MEMS high-range acceleration sensor with no lead solve the problem that the application range of an existing piezoresistive MEMS high-range acceleration sensor is limited. The piezoresistive MEMS high-range acceleration sensor with no lead comprises a substrate, a closed cavity, a first cantilever beam, a second cantilever beam, a third cantilever beam, a fourth cantilever beam, a mass block, a planar spiral inductor, a first piezoresistor, a second piezoresistor, a first capacitor, a second capacitor, a first wire hole, a second wire hole, a third wire hole, a fourth wire hole, a first electric connecting wire, a second electric connecting wire, a third electric connecting wire, a fourth electric connecting wire and a fifth electric connecting wire. The piezoresistive MEMS high-range acceleration sensor with no lead is suitable of acceleration measurement.