This invention relates to the field of robot control technology, specifically to an end-to-end closed-loop control method and system for robots based on multimodal perception fusion. It includes: a perception access layer for standardized access to data from multiple sensor types; a fusion processing layer for spatiotemporal alignment and multimodal fusion processing of the standardized access data; a decision control layer for generating execution instructions based on the fusion processing results; and an execution feedback layer for feeding back the execution status to the fusion processing layer to form closed-loop control. This technical solution can solve the problems of standardized access and real-time fusion of multi-source heterogeneous data, and construct a closed-loop control architecture with high fault tolerance and low latency.