The invention provides a Mini-LED backlight partition control system. The Mini-LED backlight partition control system comprises a video signal input module, a data processing and control module, a panel driving display module, a backlight driving module and a backlight display module. According to the method, a deep learning model among the contrast ratio, the power consumption, the system complexity and the backlight partition number is established, and the optimal backlight partition is determined. According to the system, partition images are processed, and a partition dimming algorithm for backlight brightness matrix compensation is combined, so backlight driving signals of partitions are adjusted, and area backlight brightness control matched with image information is realized. The invention has the beneficial effects that a quantitative model of the backlight partition number, the contrast ratio and the power consumption is established, the optimal partition is determined by comprehensively considering the complexity of a partition implementation scheme, and the dimming method of the backlight fuzzy model is adopted, so the real distribution condition of backlight can be reflected more accurately, the dimming accuracy of the Mini-LED area is greatly improved, and the power consumption and the contrast ratio are optimized.