349 results about "Cyclobutanes" patented technology

The present invention discloses a liquid crystal alignment agent, including a polyamic acid-polyimide copolymer and an organic solvent. The block polymer in the polyamic acid-polyimide copolymer is prepared by a diamine component comprising a structure shown in the following formula (1) and at least one dianhydride component selected from cyclobutane tetracarboxylic dianhydride shown in the following formula (3-1) and 1,3-dimethylcyclobutane tetracarboxylic dianhydride shown in the following formula (3-2); In formula (1), X1 and X2 each independently represent a single bond or an alkyl group with 1 to 6 carbon atoms; Y1 and Y2 each independently represent one or more of -NHCO-, -CONH-, -OCO-, -COO-; Ar is a nitrogen-containing heterocyclic structure. The present invention can provide a liquid crystal alignment film for a lateral electric field driven liquid crystal display element endowed with high mechanical strength and high transmittance and a liquid crystal display element having the liquid crystal alignment film.

Provided are: a curable composition that has, at high standards, curability, mechanical strength, and low viscosity; a cured product of the same; an adhesive; and a sealant. The curable composition contains an epoxy-oxetane compound represented by chemical formula (I). In the formula, the Rs are the same or different, and each represents a hydrogen atom or a C1-3 alkyl group.

The invention provides a halohydrin dehalogenase mutant and an application of the halohydrin dehalogenase mutant in synthesis of a chiral gamma-amino alcohol compound. Halogenated alcohol dehalogenase mutants enabling 2-substituted oxetane to be subjected to ring opening are obtained through the technologies of gene mining, directed evolution and the like, and the enzymes can directly perform ring opening on a substrate 2-aryl oxetane under the action of a nucleophilic reagent to generate a series of chiral gamma-amino alcohol compounds which are important precursors for synthesizing drugs. Therefore, the halohydrin dehalogenase mutants have important application value in the industry.

The invention discloses polyurethane resin with a super-hydrophobic surface and a preparation method of the polyurethane resin, and belongs to the technical field of modified polyurethane materials. According to the invention, 2, 2 '-diallyl bisphenol A and a fluorine-containing thiol monomer react to introduce a fluorine-containing carbon chain, and then fluorinated modified 2, 2'-diallyl bisphenol A and tetramethoxysilane are used for treating nano zinc oxide, so that the content of active oxygen groups is reduced, a siloxane network structure is formed, the action with water molecules is reduced, and the hydrophobicity is improved. Secondly, the 2, 2 '-diallyl bisphenol A reacts with amino propyl isobutyl POSS to generate a benzoxazine structure, the POSS structure is introduced, the nano-size effect of the benzoxazine structure fills limited movement between molecular chains, a cage-shaped structure serves as a cross-linking point, the mechanical property is improved, and hydrophobicity is achieved. When polyurethane is prepared, 3, 3-bis (hydroxymethyl) azetidine and a benzoxazine structure are subjected to ring opening crosslinking, bonding, dispersity and stability of fluorinated modified nanoparticles and a matrix are enhanced, a complex network structure is formed, the surface roughness is increased, the water contact area is reduced, and super-hydrophobicity is achieved.

Methods for treating immune thrombocytopenia comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

To provide a liquid crystal alignment agent that yields a liquid crystal alignment film with superior liquid crystal alignment properties, electric characteristics, and mechanical characteristics.SOLUTION: A liquid crystal alignment agent includes: a first polymer including a structural unit (I) derived from a diamine with a moiety represented by formula (1) and a structural unit (T) derived from a substituted cyclobutane tetracarboxylic dianhydride, where the content of the structural unit (T) is 75 mol% or more relative to the total amount of a structural unit derived from a tetracarboxylic acid derivative; and a second polymer including a structural unit (II) derived from a diamine with a moiety represented by formula (2).SELECTED DRAWING: None

Methods for treating patients with moderate-to-severe asthma comprising administering a therapeutically effective amount of at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

The invention discloses a novel method for synthesizing 3-oxo-1-cyclobutanecarboxylic acid, which comprises the following steps: taking dichloroacetyl chloride or trichloroacetyl chloride as a starting raw material, carrying out elimination reaction in a solvent under the catalytic action of alkali or Zn-Cu, and reacting the obtained dichloroketene intermediate with methyl acrylate in situ to generate 3-oxo-2, 2, 3-trimethyl-1-cyclobutanecarboxylic acid, thereby obtaining the 3-oxo-1-cyclobutanecarboxylic acid. The 3-oxo-1-cyclobutanecarboxylic acid is prepared by using 2, 2-dichloro-1-cyclobutanecarboxylic acid as a raw material, then dehalogenation and hydrolysis reactions are carried out to prepare the 3-oxo-1-cyclobutanecarboxylic acid, the 3-oxo-1-cyclobutanecarboxylic acid is a pure product with the content of 99% or above, and the total yield reaches 50% or above. The synthetic route has the advantages of mild conditions, few byproducts, high yield and environmental friendliness, and is suitable for industrial amplification.

The invention discloses a soft magnetic composite material and a preparation method thereof, and belongs to the technical field of soft magnetic materials. The preparation method of the soft magnetic composite material comprises the steps that iron, nickel, manganese, aluminum, silicon and chromium are prepared into superfine alloy powder with the D50 particle size ranging from 100 nm to 3000 nm, then the superfine alloy powder reacts with 3-aminopropyltriethoxysilane and tetraethoxysilane firstly and then reacts with cyclobutane tetracarboxylic dianhydride and 3-aminobenzophenone, and the soft magnetic composite material is prepared. The invention discloses a soft magnetic composite material with excellent direct current bias performance and excellent quality factor and a preparation method thereof.

The invention provides a preparation method of bicyclobutane, and belongs to the technical field of aerospace fuels. According to the method, the bicyclobutane fuel is efficiently synthesized through nickel-catalyzed bromocyclobutane coupling reaction, and according to the method, nickel chloride serves as a catalyst, a reducing agent manganese powder is added, and the debromination self-coupling reaction of halogenated cyclobutane is promoted. The reduction coupling fuel synthesis strategy shows high efficiency, and the conversion number (TON) of the nickel catalyst can reach 44. The reaction can be carried out in an open system at the temperature of 40 DEG C, a water-free and oxygen-free environment is not needed, the yield of the bicyclobutane fuel is 88%, and the purity of the bicyclobutane fuel is 99% or above. Fuel performance tests show that bicyclobutane has excellent physical and chemical properties, the density is 0.82 g.mL <-1 >, the combustion net heat value is 44.39 MJ.kg <-1 >, and bicyclobutane is a high-energy aerospace fuel with great potential.

Disclosed herein are novel methods for preparing 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile, including various solvate forms and intermediates thereof. Also disclosed herein are novel solvate forms and intermediates of 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile.

Methods for treating patients with wAIHA comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

The invention relates to a preparation method of octafluorocyclobutane, which comprises the following steps: mixing hexafluorocyclobutene with preheated nitrogen trifluoride, carrying out addition reaction on the mixed gas, and condensing and collecting the octafluorocyclobutane after the reaction is completed. According to the method, octafluorocyclobutane is prepared by using nitrogen trifluoride, continuous production of octafluorocyclobutane with the purity being 99 wt% or above can be achieved, the preparation method has the advantages of being low in raw material cost, simple in process, low in energy consumption, simple in product separation, good in selectivity and convenient to purify, and amplified continuous production can be achieved easily.

To provide rubber formulations that do not require the addition of curing agents, thereby reducing costs and improving sustainability.SOLUTION: Embodiments of the present disclosure are directed to rubber formulations, wherein the formulations include a statistical copolymer. The statistical copolymer includes a polymerized, crosslinkable reaction product derived from a conjugated diene monomer and vinylbenzocyclobutane. The rubber formulation is substantially free of traditional rubber curing agents.SELECTED DRAWING: Figure 1

The invention belongs to the field of medicine synthesis, and relates to a synthesis method of a medicine intermediate 3-aminooxetane-3-formic acid. The method has the advantages of cheap and easily available raw materials, non-toxic intermediate products and high yield of final products, and has industrial production prospects.

The invention provides a synthesis method of 3-ethyl-3-[(2-oxirane methoxy) methyl] oxetane (EGMO), and belongs to the technical field of fine chemical engineering. According to the method, sodium hydroxide is taken as an alkaline reagent, and a quaternary ammonium salt or quaternary phosphonium salt phase transfer catalyst is adopted to promote the effective contact of sodium salt and epichlorohydrin, so that the conversion process of preparing 3-ethyl-3-[(2-oxirane methoxy) methyl] oxetane from 3-ethyl-3-oxetane and epichlorohydrin is catalyzed. According to the method disclosed by the invention, the EGMO is synthesized by dropwise adding the epoxy chloropropane through a one-pot method, and a product with relatively high content and relatively low color number can be obtained without distillation, so that the reaction time is shortened, the side reaction of the epoxy chloropropane is reduced, the production efficiency, the product yield and the purity are improved, and the color number of the product is reduced. The preparation process is convenient to operate, simple and suitable for industrial production.

The invention provides novel polyimide. Aliphatic bio-based polyimide is synthesized through a salt monomer method. The preparation method comprises the following specific steps: 1) respectively dissolving cyclobutanetetracarboxylic acid (CBTA) and NH2 (CH2) nNH2 (n = 2, 3, 4... 20) in an organic solvent, and stirring to obtain a solution; 2) mixing the two different solutions, and separating out ion pairs to obtain corresponding crystals; and 3) carrying out thermal polymerization on the salt monomer to obtain the aliphatic polyimide. The novel polyimide is prepared through the green, environment-friendly, simple and efficient synthesis method, and the application prospect is wide.

The invention provides a spiro butane indolone derivative as well as a preparation method and application thereof, and belongs to the technical field of organic chemical synthesis. The series cyclization coupling reaction of the N-iodo aryl dicyclobutyl amide compound and the vinyl pyridine compound is realized by utilizing a photocatalytic system, and the method is used for constructing the spiro butane indolone derivative containing the pyridine structure. The spirobutane indolone derivative synthesized by the invention has an inhibition effect on H1975 human lung adenocarcinoma cells; the preparation method provided by the invention is mild in condition and simple and convenient to operate, has economical steps, provides a convenient synthesis way for the complex bioactive molecules, and has a good application prospect.

Methods for treating immune thrombocytopenia comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (PRN1008) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising at least one compound chosen from PRN1008 and pharmaceutically acceptable salts thereof are also disclosed.

The invention relates to an organic compound, an organic light-emitting device and a display panel. The organic compound has a structural formula as shown in a formula (1): # imgabs0 #. The organic compound provided by the invention contains tetrahydrocyclobutane dipyrroletetraone, so that the organic compound has an excellent tetrahydrocyclobutane dipyrroletetraone structure with a non-conjugated plane connection design; the organic compound provided by the invention has a relatively high first singlet excited state energy level and a relatively high glass transition temperature; the reasonable introduction of the trifluoromethyl group can make the material have a low refractive index; in addition, when a film layer formed by the organic compound is combined with a high-refractive-index film layer to form a covering layer and the covering layer is applied to the organic light-emitting device, the light-emitting efficiency and the color purity of the device can be remarkably improved, and the problem of visual deviation can be solved.

The invention relates to the technical field of flexible display materials, in particular to a semi-aromatic CPI film and a preparation method thereof. The invention relates to a semi-aromatic CPI film. The semi-aromatic CPI film is prepared by carrying out polymerization reaction on alicyclic dianhydride and diamine, the diamine comprises a diamine containing trifluoromethyl, a diamine containing benzimidazole and a diamine containing vinyl phenoxy; the alicyclic dianhydride comprises one or two of norbornane-2-spiro-alpha-cyclopentanone-alpha '-spiro-2'-norbornane-5, 5 ', 6, 6'-tetracarboxylic dianhydride and cyclobutane tetracarboxylic dianhydride, and the alicyclic dianhydride comprises one or two of norbornane-2-spiro-alpha-cyclopentanone-alpha '-spiro-2'-norbornane-5, 5 ', 6, in order to solve the problem that application of an existing polyimide film in a flexible substrate is limited due to the fact that optical properties, high temperature resistance, mechanical properties and dimensional thermal stability of the existing polyimide film are difficult to consider, the temperature resistance, the dimensional stability and the mechanical properties are enhanced while the optical properties of colorless transparent polyimide are kept, and the application prospect is wide. And the application of the flexible display substrate in the field of flexible display substrates is widened.

Methods for treating Sickle Cell Disease (SCD) comprising administering a BTKi, such as at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof, are disclosed.

Disclosed are two different groups of block copolymers having the general structure (I) or (III), compositions thereof, and methods of using these compositions in DSA; wherein the B fragment and the B1 fragment are polar block copolymer fragments comprising a 2-methylene alkanoic acid alkyl ester-derived repeat unit, a lactone-derived repeat unit, an ethylene oxide-derived repeat unit, an oxetane or cyclic carbonate-derived repeat unit; l and L1 are a direct valence bond or a linking moiety derived from 1, 1-diarylethene; fragments A and A1 are non-polar block copolymer fragments comprising styrenic repeat units, E ', E' ', E3 and E4 are different types of end groups, A2 is a block fragment derived from an olefinic hydrocarbon or diene having a Tg of from about-5 DEG C to about-50 DEG C, and in structure (I), is multi-linked by an oligomeric flexible tether group at different positions as summarized: E'-A-L-B-E ''(I) E3-A1-A2-L1-B1-E4 (III).

The invention relates to the field of polyether molecule synthesis and energetic materials, in particular to branched chain type fluorine-containing hydroxyl-terminated copolyether and a preparation method thereof. The problems that combustion is insufficient and energy release efficiency is low in a common technology are solved. Comprising the following steps: purging a flask with nitrogen to remove internal air, adding a solvent and hydroxyl-terminated polyether, stirring until the hydroxyl-terminated polyether and the solvent are uniformly mixed, then adding a catalyst, mixing and reacting to prepare a reaction liquid, dropwise adding a fluorine-containing oxetane monomer into the reaction liquid through a constant-pressure separating funnel, after the reaction is finished, adding deionized water, continuously stirring, and cooling to room temperature to obtain the fluorine-containing oxetane monomer. And neutralizing and washing with an alkaline solution, standing and separating liquid after washing to be neutral, and removing the solvent through rotary evaporation of an organic phase to obtain a final product. According to the branched chain type fluorine-containing hydroxyl-terminated copolyether disclosed by the invention, a fluorine component is introduced into a typical polyurethane adhesive basic raw material, so that the branched chain type fluorine-containing hydroxyl-terminated copolyether is endowed with a special energy release effect, combustion of aluminum powder in a solid propellant can be effectively promoted, and agglomeration and sintering phenomena of the aluminum powder are reduced.

The application discloses an alkali-resistant polyester loose nanofiltration membrane based on 2,2,4,4-tetramethyl-1,3-cyclobutanediol and a preparation method and application thereof, and belongs to the field of membrane separation technology. In the application, 2,2,4,4-tetramethyl-1,3-cyclobutanediol is used as a water-phase monomer, and interfacial polymerization is carried out on the surface of an ultrafiltration membrane under the action of trimesoyl chloride and an organic base to obtain the alkali-resistant polyester loose nanofiltration membrane based on 2,2,4,4-tetramethyl-1,3-cyclobutanediol. The 2,2,4,4-tetramethyl-1,3-cyclobutanediol used in the application contains a cyclobutane rigid ring structure, and four methyl substituents are carried on the ring, thereby providing steric hindrance and giving the polymer skeleton high rigidity. The polyester loose nanofiltration membrane prepared by the application has high permeation flux, can effectively separate dyes and inorganic salts, has strong alkali resistance, and still exhibits excellent separation performance after strong alkali treatment. The preparation method provided by the application is simple in process and easy to operate, and provides a reference direction for preparing the alkali-resistant polyester nanofiltration membrane.

The invention discloses a radio-frequency coaxial cable working at an ultra-cut-off frequency and a preparation method of the radio-frequency coaxial cable. The coaxial cable provided by the invention sequentially comprises an inner conductor, a foaming insulating layer and an outer conductor from inside to outside, the inner conductor and the outer conductor are coaxially nested; the outer conductor is an embossed copper pipe; the foaming insulating layer is made of foaming polyethylene; the foamed polyethylene is manufactured by physical foaming by adopting hexafluorocyclobutane as a foaming agent, a closed-cell structure with the closed-cell rate larger than 90% and the pore size of 10-100 microns is formed, and the outer conductor and the foamed insulating layer are subjected to heat treatment at the temperature of 80-125 DEG C to induce secondary pore growth. According to the invention, by utilizing the principle of secondary growth of bubbles, the phenomena of stress accumulation and nonuniform air holes caused by the fact that bubble tissues of the foaming insulating layer are pressed in the embossing process of the outer conductor are improved, scattering and reflection of signals are reduced, and the cable can still keep excellent standing-wave ratio performance in an adjacent wave band exceeding a cut-off frequency; therefore, the 5G communication requirement of the large-size coaxial cable with the wave band of 2.7 G to 3.3G is met.

To provide benzenesulfonamide compounds and their use as therapeutic agents.SOLUTION: This invention is directed to benzenesulfonamide compounds (which are compounds as stereoisomers, enantiomers or tautomers thereof or mixtures thereof), or pharmaceutically acceptable salts, solvates or prodrugs thereof, for treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy. Of this embodiment, a preferred compound is 4-((1-benzylazetidin-3-yl)oxy)-3-chloro-N-(thiazol-2-yl)benzene-sulfonamide.SELECTED DRAWING: None

To provide a type I receptor tyrosine kinase inhibitor.SOLUTION: Or a pharmaceutically acceptable salt thereof. Specific examples thereof include N - (4 - ([1,2,4] triazolo [1, 5-c] pyrimidin-7-yloxy) - 3-methylphenyl) - 5 - (3 - (dimethylamino) azetidin-1-yl) - 6-methoxyquinazolin-4-amine.SELECTED DRAWING: None

The invention discloses an ultra-microporous branched polyaryl piperidinyl anion exchange membrane material as well as a preparation method and application thereof, and relates to the field of anion exchange membrane materials for producing hydrogen by electrolyzing water. According to the ultra-microporous branched polyaryl piperidinyl anion exchange membrane material, a four-functionality branching agent with a structure shown in a formula I is introduced into a polymer structural unit of polyterphenyl piperidone, and a polyaryl piperidinyl compound with a four-branch norbornene bis-benzocyclobutane structure is formed. By adopting the technical scheme, the structural rigidity of a polymer skeleton is improved, the formation of a large number of ultra-microporous structures is promoted, the ionic conductivity of the membrane material is effectively improved, and meanwhile, the problem of relatively poor dimensional stability caused by excessive water absorption of the membrane material is solved; the prepared anion exchange membrane has a wide application prospect in the field of hydrogen production by water electrolysis.