285 results about "Cyclobutanes" patented technology

Provided are: a curable composition that has, at high standards, curability, mechanical strength, and low viscosity; a cured product of the same; an adhesive; and a sealant. The curable composition contains an epoxy-oxetane compound represented by chemical formula (I). In the formula, the Rs are the same or different, and each represents a hydrogen atom or a C1-3 alkyl group.

The invention provides a halohydrin dehalogenase mutant and an application of the halohydrin dehalogenase mutant in synthesis of a chiral gamma-amino alcohol compound. Halogenated alcohol dehalogenase mutants enabling 2-substituted oxetane to be subjected to ring opening are obtained through the technologies of gene mining, directed evolution and the like, and the enzymes can directly perform ring opening on a substrate 2-aryl oxetane under the action of a nucleophilic reagent to generate a series of chiral gamma-amino alcohol compounds which are important precursors for synthesizing drugs. Therefore, the halohydrin dehalogenase mutants have important application value in the industry.

Methods for treating immune thrombocytopenia comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

Methods for treating patients with moderate-to-severe asthma comprising administering a therapeutically effective amount of at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

The invention provides a preparation method of bicyclobutane, and belongs to the technical field of aerospace fuels. According to the method, the bicyclobutane fuel is efficiently synthesized through nickel-catalyzed bromocyclobutane coupling reaction, and according to the method, nickel chloride serves as a catalyst, a reducing agent manganese powder is added, and the debromination self-coupling reaction of halogenated cyclobutane is promoted. The reduction coupling fuel synthesis strategy shows high efficiency, and the conversion number (TON) of the nickel catalyst can reach 44. The reaction can be carried out in an open system at the temperature of 40 DEG C, a water-free and oxygen-free environment is not needed, the yield of the bicyclobutane fuel is 88%, and the purity of the bicyclobutane fuel is 99% or above. Fuel performance tests show that bicyclobutane has excellent physical and chemical properties, the density is 0.82 g.mL <-1 >, the combustion net heat value is 44.39 MJ.kg <-1 >, and bicyclobutane is a high-energy aerospace fuel with great potential.

Disclosed herein are novel methods for preparing 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile, including various solvate forms and intermediates thereof. Also disclosed herein are novel solvate forms and intermediates of 2-[(3R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4[4-(oxetan-3-yl)piperazin-1-yl]-pent-2-enenitrile.

Methods for treating patients with wAIHA comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

The invention relates to a preparation method of octafluorocyclobutane, which comprises the following steps: mixing hexafluorocyclobutene with preheated nitrogen trifluoride, carrying out addition reaction on the mixed gas, and condensing and collecting the octafluorocyclobutane after the reaction is completed. According to the method, octafluorocyclobutane is prepared by using nitrogen trifluoride, continuous production of octafluorocyclobutane with the purity being 99 wt% or above can be achieved, the preparation method has the advantages of being low in raw material cost, simple in process, low in energy consumption, simple in product separation, good in selectivity and convenient to purify, and amplified continuous production can be achieved easily.

The invention provides a spiro butane indolone derivative as well as a preparation method and application thereof, and belongs to the technical field of organic chemical synthesis. The series cyclization coupling reaction of the N-iodo aryl dicyclobutyl amide compound and the vinyl pyridine compound is realized by utilizing a photocatalytic system, and the method is used for constructing the spiro butane indolone derivative containing the pyridine structure. The spirobutane indolone derivative synthesized by the invention has an inhibition effect on H1975 human lung adenocarcinoma cells; the preparation method provided by the invention is mild in condition and simple and convenient to operate, has economical steps, provides a convenient synthesis way for the complex bioactive molecules, and has a good application prospect.

Methods for treating immune thrombocytopenia comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (PRN1008) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising at least one compound chosen from PRN1008 and pharmaceutically acceptable salts thereof are also disclosed.

The invention relates to an organic compound, an organic light-emitting device and a display panel. The organic compound has a structural formula as shown in a formula (1): # imgabs0 #. The organic compound provided by the invention contains tetrahydrocyclobutane dipyrroletetraone, so that the organic compound has an excellent tetrahydrocyclobutane dipyrroletetraone structure with a non-conjugated plane connection design; the organic compound provided by the invention has a relatively high first singlet excited state energy level and a relatively high glass transition temperature; the reasonable introduction of the trifluoromethyl group can make the material have a low refractive index; in addition, when a film layer formed by the organic compound is combined with a high-refractive-index film layer to form a covering layer and the covering layer is applied to the organic light-emitting device, the light-emitting efficiency and the color purity of the device can be remarkably improved, and the problem of visual deviation can be solved.

The invention relates to the technical field of flexible display materials, in particular to a semi-aromatic CPI film and a preparation method thereof. The invention relates to a semi-aromatic CPI film. The semi-aromatic CPI film is prepared by carrying out polymerization reaction on alicyclic dianhydride and diamine, the diamine comprises a diamine containing trifluoromethyl, a diamine containing benzimidazole and a diamine containing vinyl phenoxy; the alicyclic dianhydride comprises one or two of norbornane-2-spiro-alpha-cyclopentanone-alpha '-spiro-2'-norbornane-5, 5 ', 6, 6'-tetracarboxylic dianhydride and cyclobutane tetracarboxylic dianhydride, and the alicyclic dianhydride comprises one or two of norbornane-2-spiro-alpha-cyclopentanone-alpha '-spiro-2'-norbornane-5, 5 ', 6, in order to solve the problem that application of an existing polyimide film in a flexible substrate is limited due to the fact that optical properties, high temperature resistance, mechanical properties and dimensional thermal stability of the existing polyimide film are difficult to consider, the temperature resistance, the dimensional stability and the mechanical properties are enhanced while the optical properties of colorless transparent polyimide are kept, and the application prospect is wide. And the application of the flexible display substrate in the field of flexible display substrates is widened.

Methods for treating Sickle Cell Disease (SCD) comprising administering a BTKi, such as at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof, are disclosed.

The invention relates to the field of polyether molecule synthesis and energetic materials, in particular to branched chain type fluorine-containing hydroxyl-terminated copolyether and a preparation method thereof. The problems that combustion is insufficient and energy release efficiency is low in a common technology are solved. Comprising the following steps: purging a flask with nitrogen to remove internal air, adding a solvent and hydroxyl-terminated polyether, stirring until the hydroxyl-terminated polyether and the solvent are uniformly mixed, then adding a catalyst, mixing and reacting to prepare a reaction liquid, dropwise adding a fluorine-containing oxetane monomer into the reaction liquid through a constant-pressure separating funnel, after the reaction is finished, adding deionized water, continuously stirring, and cooling to room temperature to obtain the fluorine-containing oxetane monomer. And neutralizing and washing with an alkaline solution, standing and separating liquid after washing to be neutral, and removing the solvent through rotary evaporation of an organic phase to obtain a final product. According to the branched chain type fluorine-containing hydroxyl-terminated copolyether disclosed by the invention, a fluorine component is introduced into a typical polyurethane adhesive basic raw material, so that the branched chain type fluorine-containing hydroxyl-terminated copolyether is endowed with a special energy release effect, combustion of aluminum powder in a solid propellant can be effectively promoted, and agglomeration and sintering phenomena of the aluminum powder are reduced.

The application discloses an alkali-resistant polyester loose nanofiltration membrane based on 2,2,4,4-tetramethyl-1,3-cyclobutanediol and a preparation method and application thereof, and belongs to the field of membrane separation technology. In the application, 2,2,4,4-tetramethyl-1,3-cyclobutanediol is used as a water-phase monomer, and interfacial polymerization is carried out on the surface of an ultrafiltration membrane under the action of trimesoyl chloride and an organic base to obtain the alkali-resistant polyester loose nanofiltration membrane based on 2,2,4,4-tetramethyl-1,3-cyclobutanediol. The 2,2,4,4-tetramethyl-1,3-cyclobutanediol used in the application contains a cyclobutane rigid ring structure, and four methyl substituents are carried on the ring, thereby providing steric hindrance and giving the polymer skeleton high rigidity. The polyester loose nanofiltration membrane prepared by the application has high permeation flux, can effectively separate dyes and inorganic salts, has strong alkali resistance, and still exhibits excellent separation performance after strong alkali treatment. The preparation method provided by the application is simple in process and easy to operate, and provides a reference direction for preparing the alkali-resistant polyester nanofiltration membrane.

The invention discloses a radio-frequency coaxial cable working at an ultra-cut-off frequency and a preparation method of the radio-frequency coaxial cable. The coaxial cable provided by the invention sequentially comprises an inner conductor, a foaming insulating layer and an outer conductor from inside to outside, the inner conductor and the outer conductor are coaxially nested; the outer conductor is an embossed copper pipe; the foaming insulating layer is made of foaming polyethylene; the foamed polyethylene is manufactured by physical foaming by adopting hexafluorocyclobutane as a foaming agent, a closed-cell structure with the closed-cell rate larger than 90% and the pore size of 10-100 microns is formed, and the outer conductor and the foamed insulating layer are subjected to heat treatment at the temperature of 80-125 DEG C to induce secondary pore growth. According to the invention, by utilizing the principle of secondary growth of bubbles, the phenomena of stress accumulation and nonuniform air holes caused by the fact that bubble tissues of the foaming insulating layer are pressed in the embossing process of the outer conductor are improved, scattering and reflection of signals are reduced, and the cable can still keep excellent standing-wave ratio performance in an adjacent wave band exceeding a cut-off frequency; therefore, the 5G communication requirement of the large-size coaxial cable with the wave band of 2.7 G to 3.3G is met.

To provide benzenesulfonamide compounds and their use as therapeutic agents.SOLUTION: This invention is directed to benzenesulfonamide compounds (which are compounds as stereoisomers, enantiomers or tautomers thereof or mixtures thereof), or pharmaceutically acceptable salts, solvates or prodrugs thereof, for treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy. Of this embodiment, a preferred compound is 4-((1-benzylazetidin-3-yl)oxy)-3-chloro-N-(thiazol-2-yl)benzene-sulfonamide.SELECTED DRAWING: None

To provide a type I receptor tyrosine kinase inhibitor.SOLUTION: Or a pharmaceutically acceptable salt thereof. Specific examples thereof include N - (4 - ([1,2,4] triazolo [1, 5-c] pyrimidin-7-yloxy) - 3-methylphenyl) - 5 - (3 - (dimethylamino) azetidin-1-yl) - 6-methoxyquinazolin-4-amine.SELECTED DRAWING: None

The invention discloses an ultra-microporous branched polyaryl piperidinyl anion exchange membrane material as well as a preparation method and application thereof, and relates to the field of anion exchange membrane materials for producing hydrogen by electrolyzing water. According to the ultra-microporous branched polyaryl piperidinyl anion exchange membrane material, a four-functionality branching agent with a structure shown in a formula I is introduced into a polymer structural unit of polyterphenyl piperidone, and a polyaryl piperidinyl compound with a four-branch norbornene bis-benzocyclobutane structure is formed. By adopting the technical scheme, the structural rigidity of a polymer skeleton is improved, the formation of a large number of ultra-microporous structures is promoted, the ionic conductivity of the membrane material is effectively improved, and meanwhile, the problem of relatively poor dimensional stability caused by excessive water absorption of the membrane material is solved; the prepared anion exchange membrane has a wide application prospect in the field of hydrogen production by water electrolysis.

The invention provides a benzo-silicon hybrid eight-membered ring compound with a stereo axis, which is constructed based on palladium-catalyzed alkyne insertion / C-H activation / ring expansion. According to the method, aryl halide, alkyne and silacyclobutane which are simple and easy to obtain are used as initial raw materials and are stirred to react in an organic solvent at the temperature of 40-120 DEG C under the action of a palladium catalyst, a phosphine ligand and alkali, and the benzo-silicon hybrid eight-membered ring compound can be obtained. The method has the advantages of cheap and easily available raw materials, mild reaction conditions, simple preparation process, good regioselectivity, wide substrate application range, easy amplification and the like.

A method for inhibiting or preventing polymerization of a polymerization composition comprises: adding at least one inhibitor(s) to the polymerization composition to stabilize and inhibit the polymerization of the polymerization composition, wherein the polymerization composition contains disilacyclobutane monomers, wherein the inhibitor is selected from amine compounds, quaternary ammonium salts or metal chelating agents.

The invention provides a 1, 4-dihydrobenzosilacyclohexane compound containing a polyfunctional group structure as well as a preparation method and application thereof, the preparation method specifically comprises the following steps: in the presence of a phosphine ligand, a palladium catalyst and a reaction medium, carrying out silicon-carbon bond activation and cycloaddition reaction on phenylpropargyl aldehyde and benzosilacyclobutane to prepare the 1, 4-dihydrobenzosilacyclohexane compound containing the polyfunctional group structure, and carrying out cycloaddition reaction on the 1, 4-dihydrobenzosilacyclohexane compound containing the polyfunctional group structure to obtain the 1, 4-dihydrobenzosilacyclohexane compound containing the polyfunctional group structure. The 2, 4-dihydrobenzo-silacyclohexane compound disclosed by the invention is applied to both material chemistry and medicinal chemistry. According to the present invention, the reaction condition is mild, the operation is simple, the substrate universality is strong, the crude product is subjected to rapid column chromatography impurity removal and vacuum concentration to obtain the pure product, the post-treatment is convenient, the finally obtained chemical selection is high, and the silicon-containing cyclohexane structure precursor can be widely used in various organic reactions and drug synthesis, and has considerable potential application value.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a method for efficiently preparing cyclobutane derivatives. Comprising the following steps: dissolving 4-chloro-7H-pyrrolo [2, 3-d] pyrimidine and chloromethyl pivalate in 1, 4-dioxane, and adding an acid binding agent for reaction to obtain a reaction solution; the preparation method comprises the following steps: adding 1-(1-ethoxyethyl)-4-pyrazol boronic acid pinacol ester, purified water, a catalyst and an acid-binding agent into a reaction kettle, carrying out Suzuki reaction, separating liquid, adding activated carbon into an upper organic phase for decoloration, adding an organic solution containing hydrogen chloride for crystallization, and filtering to obtain a wet product; and dissolving the wet product and 2-[1-(ethylsulfonyl)-3-azacyclobutane] acetonitrile in 1, 4-dioxane, and reacting under an alkaline condition to obtain the cyclobutane derivative. According to the preparation method, synthesis is performed through a one-pot four-step reaction, a solvent only relates to 1, 4-dioxane and water, and post-treatment is simple, convenient and efficient.

The application discloses a preparation method of baricitinib, and belongs to the technical field of drug synthesis. The method comprises the following steps: firstly, 2-[1-(ethylsulfonyl)-3-azetidinyl]acetonitrile and 4-pyrazole boron pinacol ester are subjected to a Michael addition reaction to obtain 1-(ethylsulfonyl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-3-azetidine acetonitrile as an intermediate I; secondly, a protection group is introduced on the amino group of 4-chloropyrrolopyrimidine to obtain an intermediate II; finally, the intermediate I and the intermediate II are subjected to a Suzuki coupling process by adopting a method of combining a nickel pre-catalyst with a supporting ligand to obtain the baricitinib. The preparation method creatively realizes cross coupling of the baricitinib by adopting the cheap metal nickel as a catalyst, avoids the use of a heavy metal palladium catalyst, and has the advantages of low cost, low toxicity, small pollution, green environmental protection and the like.

The present invention relates to a method for preparing a hydroxyl- or epoxy-group-containing organic phosphate from an epoxy compound, comprising the following steps: mixing a P(O)-OH compound and an epoxy compound under air, stirring for reaction, cooling, and purifying to obtain a hydroxyl- or epoxy-group-containing organic phosphate as shown in Formula I, wherein the epoxy compound is one of epichlorohydrin, methylepichlorohydrin, oxetane, and cyclohexene oxide, and the epoxy compound serves as both a reaction substrate and a reaction solvent; R 1 、R 2 are selected from one or two of aryl, substituted aryl, aliphatic, ether, hydroxyl and hydrogen atoms; R 3 The present invention provides a method for preparing an organophosphate compound directly from a P(O)-OH compound and an epoxy compound under solvent-free and additive-free conditions. The raw materials are inexpensive, readily available, green and stable, with high atom economy. The reaction conditions are simple and mild, and the reaction can be carried out efficiently without any additives.

A method for producing 1, 1, 2, 2-tetrafluorocyclobutane, said method comprising a reaction step in which a compound represented by formula 1 and ethylene are reacted using a starting material composition comprising the compound represented by formula 1 and ethylene. In the formula 1, X1 is a hydrogen atom, a fluorine atom or a chlorine atom, and X2 is a fluorine atom, a chlorine atom,-CO2H,-CF3 or-CF2Cl.

The application discloses a preparation method of 1,3-disubstituted cyclobutane-1,2,3,4-cyclobutane tetra carboxylic dianhydride, which comprises the following steps: (1) uniformly stirring citraconic anhydride, ethyl acetate and a catalyst, and performing microwave continuous flow reaction; after the reaction is completed, filtration is performed to obtain 1,3-dmcbda crude product I; (2) adding acetic anhydride and stirring under heating, then reducing to room temperature, and performing filtration to obtain 1,3-dmcbda crude product II; then adding acetone, heating to reflux, then reducing to room temperature, and performing vacuum drying to obtain 1,3-dmcbda fine product. The preparation method can make the 1,3-dmcbda product have high yield and high purity, and is suitable for industrial production.

The present invention relates to the technical field of carbon nanotube modification, specifically a flame-retardant carbon nanotube conductive material and a preparation process thereof. The method comprises the following steps: S1: reacting chlorinated carbon nanotubes with 4-aminobenzophenone and DOPO in sequence to obtain DOPO-carbon nanotubes; S2: reacting chain polyphosphazenes with (1-hydroxyallyl)trimethylsilane and oxetane-3-thiol in sequence to obtain oxacyclic-chain polyphosphazenes; and S3: mixing DOPO-carbon nanotubes, oxacyclic-chain polyphosphazenes, and pyrrole to prepare the flame-retardant carbon nanotube conductive material.

Provided are a curable composition, a curable ink composition, and a curable ink composition for inkjet, each of which has low viscosity, low volatility, and curability. And methods of using these compositions are provided. The curable composition contains an epoxy / oxetane compound represented by chemical formula (I). In the formula, n is the same or different and represents an integer of 2-5.