217 results about "Cyclobutanes" patented technology

The invention provides a halohydrin dehalogenase mutant and an application of the halohydrin dehalogenase mutant in synthesis of a chiral gamma-amino alcohol compound. Halogenated alcohol dehalogenase mutants enabling 2-substituted oxetane to be subjected to ring opening are obtained through the technologies of gene mining, directed evolution and the like, and the enzymes can directly perform ring opening on a substrate 2-aryl oxetane under the action of a nucleophilic reagent to generate a series of chiral gamma-amino alcohol compounds which are important precursors for synthesizing drugs. Therefore, the halohydrin dehalogenase mutants have important application value in the industry.

The invention provides a preparation method of bicyclobutane, and belongs to the technical field of aerospace fuels. According to the method, the bicyclobutane fuel is efficiently synthesized through nickel-catalyzed bromocyclobutane coupling reaction, and according to the method, nickel chloride serves as a catalyst, a reducing agent manganese powder is added, and the debromination self-coupling reaction of halogenated cyclobutane is promoted. The reduction coupling fuel synthesis strategy shows high efficiency, and the conversion number (TON) of the nickel catalyst can reach 44. The reaction can be carried out in an open system at the temperature of 40 DEG C, a water-free and oxygen-free environment is not needed, the yield of the bicyclobutane fuel is 88%, and the purity of the bicyclobutane fuel is 99% or above. Fuel performance tests show that bicyclobutane has excellent physical and chemical properties, the density is 0.82 g.mL <-1 >, the combustion net heat value is 44.39 MJ.kg <-1 >, and bicyclobutane is a high-energy aerospace fuel with great potential.

Methods for treating patients with wAIHA comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

Methods for treating Sickle Cell Disease (SCD) comprising administering a BTKi, such as at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof, are disclosed.

The application discloses an alkali-resistant polyester loose nanofiltration membrane based on 2,2,4,4-tetramethyl-1,3-cyclobutanediol and a preparation method and application thereof, and belongs to the field of membrane separation technology. In the application, 2,2,4,4-tetramethyl-1,3-cyclobutanediol is used as a water-phase monomer, and interfacial polymerization is carried out on the surface of an ultrafiltration membrane under the action of trimesoyl chloride and an organic base to obtain the alkali-resistant polyester loose nanofiltration membrane based on 2,2,4,4-tetramethyl-1,3-cyclobutanediol. The 2,2,4,4-tetramethyl-1,3-cyclobutanediol used in the application contains a cyclobutane rigid ring structure, and four methyl substituents are carried on the ring, thereby providing steric hindrance and giving the polymer skeleton high rigidity. The polyester loose nanofiltration membrane prepared by the application has high permeation flux, can effectively separate dyes and inorganic salts, has strong alkali resistance, and still exhibits excellent separation performance after strong alkali treatment. The preparation method provided by the application is simple in process and easy to operate, and provides a reference direction for preparing the alkali-resistant polyester nanofiltration membrane.

To provide a type I receptor tyrosine kinase inhibitor.SOLUTION: Or a pharmaceutically acceptable salt thereof. Specific examples thereof include N - (4 - ([1,2,4] triazolo [1, 5-c] pyrimidin-7-yloxy) - 3-methylphenyl) - 5 - (3 - (dimethylamino) azetidin-1-yl) - 6-methoxyquinazolin-4-amine.SELECTED DRAWING: None

The invention discloses an ultra-microporous branched polyaryl piperidinyl anion exchange membrane material as well as a preparation method and application thereof, and relates to the field of anion exchange membrane materials for producing hydrogen by electrolyzing water. According to the ultra-microporous branched polyaryl piperidinyl anion exchange membrane material, a four-functionality branching agent with a structure shown in a formula I is introduced into a polymer structural unit of polyterphenyl piperidone, and a polyaryl piperidinyl compound with a four-branch norbornene bis-benzocyclobutane structure is formed. By adopting the technical scheme, the structural rigidity of a polymer skeleton is improved, the formation of a large number of ultra-microporous structures is promoted, the ionic conductivity of the membrane material is effectively improved, and meanwhile, the problem of relatively poor dimensional stability caused by excessive water absorption of the membrane material is solved; the prepared anion exchange membrane has a wide application prospect in the field of hydrogen production by water electrolysis.

A method for inhibiting or preventing polymerization of a polymerization composition comprises: adding at least one inhibitor(s) to the polymerization composition to stabilize and inhibit the polymerization of the polymerization composition, wherein the polymerization composition contains disilacyclobutane monomers, wherein the inhibitor is selected from amine compounds, quaternary ammonium salts or metal chelating agents.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a method for efficiently preparing cyclobutane derivatives. Comprising the following steps: dissolving 4-chloro-7H-pyrrolo [2, 3-d] pyrimidine and chloromethyl pivalate in 1, 4-dioxane, and adding an acid binding agent for reaction to obtain a reaction solution; the preparation method comprises the following steps: adding 1-(1-ethoxyethyl)-4-pyrazol boronic acid pinacol ester, purified water, a catalyst and an acid-binding agent into a reaction kettle, carrying out Suzuki reaction, separating liquid, adding activated carbon into an upper organic phase for decoloration, adding an organic solution containing hydrogen chloride for crystallization, and filtering to obtain a wet product; and dissolving the wet product and 2-[1-(ethylsulfonyl)-3-azacyclobutane] acetonitrile in 1, 4-dioxane, and reacting under an alkaline condition to obtain the cyclobutane derivative. According to the preparation method, synthesis is performed through a one-pot four-step reaction, a solvent only relates to 1, 4-dioxane and water, and post-treatment is simple, convenient and efficient.

The application discloses a preparation method of baricitinib, and belongs to the technical field of drug synthesis. The method comprises the following steps: firstly, 2-[1-(ethylsulfonyl)-3-azetidinyl]acetonitrile and 4-pyrazole boron pinacol ester are subjected to a Michael addition reaction to obtain 1-(ethylsulfonyl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-3-azetidine acetonitrile as an intermediate I; secondly, a protection group is introduced on the amino group of 4-chloropyrrolopyrimidine to obtain an intermediate II; finally, the intermediate I and the intermediate II are subjected to a Suzuki coupling process by adopting a method of combining a nickel pre-catalyst with a supporting ligand to obtain the baricitinib. The preparation method creatively realizes cross coupling of the baricitinib by adopting the cheap metal nickel as a catalyst, avoids the use of a heavy metal palladium catalyst, and has the advantages of low cost, low toxicity, small pollution, green environmental protection and the like.

A method for producing 1, 1, 2, 2-tetrafluorocyclobutane, said method comprising a reaction step in which a compound represented by formula 1 and ethylene are reacted using a starting material composition comprising the compound represented by formula 1 and ethylene. In the formula 1, X1 is a hydrogen atom, a fluorine atom or a chlorine atom, and X2 is a fluorine atom, a chlorine atom,-CO2H,-CF3 or-CF2Cl.

The application discloses a preparation method of 1,3-disubstituted cyclobutane-1,2,3,4-cyclobutane tetra carboxylic dianhydride, which comprises the following steps: (1) uniformly stirring citraconic anhydride, ethyl acetate and a catalyst, and performing microwave continuous flow reaction; after the reaction is completed, filtration is performed to obtain 1,3-dmcbda crude product I; (2) adding acetic anhydride and stirring under heating, then reducing to room temperature, and performing filtration to obtain 1,3-dmcbda crude product II; then adding acetone, heating to reflux, then reducing to room temperature, and performing vacuum drying to obtain 1,3-dmcbda fine product. The preparation method can make the 1,3-dmcbda product have high yield and high purity, and is suitable for industrial production.

The present invention relates to the technical field of carbon nanotube modification, specifically a flame-retardant carbon nanotube conductive material and a preparation process thereof. The method comprises the following steps: S1: reacting chlorinated carbon nanotubes with 4-aminobenzophenone and DOPO in sequence to obtain DOPO-carbon nanotubes; S2: reacting chain polyphosphazenes with (1-hydroxyallyl)trimethylsilane and oxetane-3-thiol in sequence to obtain oxacyclic-chain polyphosphazenes; and S3: mixing DOPO-carbon nanotubes, oxacyclic-chain polyphosphazenes, and pyrrole to prepare the flame-retardant carbon nanotube conductive material.

Provided are a curable composition, a curable ink composition, and a curable ink composition for inkjet, each of which has low viscosity, low volatility, and curability. And methods of using these compositions are provided. The curable composition contains an epoxy / oxetane compound represented by chemical formula (I). In the formula, n is the same or different and represents an integer of 2-5.

A novel crystalline form of a GLP-1 receptor agonist, its preparation method, its pharmaceutical composition, and its use are provided. The GLP-1 receptor agonist is designated Compound I, i.e., (S)-2-((4-(6-((2-fluoro-4-(oxetan-3-yl)benzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylic acid.

The invention provides a compound of carboplatin and 1, 1-cyclobutane dicarboxylic acid and a detection method of the compound. A nuclear magnetic resonance hydrogen spectrum and a nuclear magnetic resonance carbon spectrum of the carboplatin and 1, 1-cyclobutane dicarboxylic acid eutectic compound in a D-(+)-glucose heavy water solution with the mass fraction of 5%, a nuclear magnetic resonance hydrogen spectrum and a nuclear magnetic resonance carbon spectrum of carboplatin in a 1.2. 3. 4-cyclobutane tetracarboxylic acid heavy water solution with the mass fraction of 2%, and a 1, 1-cyclobutane dicarboxylic acid eutectic compound with the mass fraction of 1, 1-cyclobutane dicarboxylic acid are measured. A nuclear magnetic resonance hydrogen spectrum and a nuclear magnetic resonance carbon spectrum of carboplatin and 1, 1-cyclobutane dicarboxylic acid in a D-(+)-glucose heavy water solution with the mass fraction of 5% are analyzed, and the structure of the carboplatin and 1, 1-cyclobutane dicarboxylic acid eutectic compound in water is determined by analyzing the chemical shift change of characteristic carbon atoms in the nuclear magnetic resonance carbon spectrum.

The invention provides a preparation method of an ivabradine hydrochloride key intermediate (I), the method is characterized in that (1S)-4, 5-dimethoxy-1-(aminomethyl) benzocyclobutane is used as a raw material, and (1S)-4, 5-dimethoxy-1-[(methylamino) methyl] benzocyclobutane hydrochloride (I) is obtained through condensation and reduction reaction, the method is simple to operate, the yield is high, and the method is suitable for industrial production. The method has the advantages of mild conditions, high reaction yield, significantly reduced cost, avoidance of high toxic substances, significantly improved environmental benefits, and suitableness for large-scale industrial production.

The present invention relates to (3)-phenoxyazetidin-(1)-yl-heteroarylpyrrolidine derivatives of general formula (I) that are agonists of GPR52, useful for the treatment of central nervous system disorders and other disorders. The present invention also relates to (3)-phenoxyazetidin-(1)-yl-heteroarylpyrrolidine derivatives of general formula (I) for use as medicines, pharmaceutical compositions comprising at least one compound of general formula (I) and methods for preparing pharmaceutical compositions, as well as methods for preparing the compounds according to the invention.

The application belongs to the field of organic synthesis, and discloses a preparation method of 1-amino cyclobutanecarboxylic acid, which comprises the following steps: S1. 1-cyanocyclobutyl carboxylic acid ethyl ester is reacted under acidic conditions to obtain 1-formylaminocyclobutane carboxylic acid ethyl ester; S2. 1-formylaminocyclobutane carboxylic acid ethyl ester is reacted under the action of sodium hypochlorite to obtain 1-amino cyclobutanecarboxylic acid ethyl ester; S3. 1-amino cyclobutanecarboxylic acid ethyl ester is reacted under the action of a base catalyst and di-tert-butyl dicarbonate to obtain BOC-1-amino cyclobutane carboxylic acid ethyl ester; and S4. BOC-1-amino cyclobutane carboxylic acid ethyl ester is reacted under the action of an acid catalyst to obtain 1-amino cyclobutanecarboxylic acid. The product obtained by the preparation method is pure, has no inorganic salt residue, and is simple to operate, low in cost and suitable for industrialized production.

The application discloses a kind of self-reinforced nylon materials and preparation method thereof, and the self-reinforced nylon material contains the benzocyclobutane structure sensitive to force.By interface polycondensation method, the benzocyclobutane structure is introduced into nylon main chain.When the matrix material is subjected to destructive force, the benzocyclobutane structure unit undergoes ring-opening isomerization, and simultaneously reacts with the bifunctional group crosslinking agent in the matrix material, plays the crosslinking self-reinforcing role.The technical route of the application is simple, the required cost is low, and the prepared nylon material can be used in some engineering plastic application fields with harsh service conditions, and can reduce the risk of component failure.

A method for producing a high-purity cyclobutane derivative, comprising: adding a tetrahydrofuran derivative into a starting mixture containing cyclobutane derivatives having structures represented by formula (1) and formula (2) to form a cyclobutane derivative mixed solution, where R1 is an alkyl group having 1 to 20 carbon atoms; and filtering the cyclobutane derivative mixed solution to obtain a solid containing the cyclobutane derivative with the structure as shown in the formula (1). Formula (1) and formula (2).

Provided are: a resin composition which contains a resin having a polymerizable group and a photopolymerization initiator, wherein the resin has at least one partial structure represented by formula (A-1a) or formula (A-1b), and the proportion of the molar amount of a cyclobutane ring having a trans-type steric conformation to the total molar amount of cyclobutane rings contained in the resin is 80% or more; a cured product which is obtained by curing the composition and a method for producing the cured product; a laminate which contains the cured product and a method for producing the laminate; a semiconductor device and a method for producing the semiconductor device; and a novel resin.

The invention relates to a preparation method of a dimer-mediated organic polymer single crystal, and belongs to the technical field of organic polymer single crystals. The preparation method comprises the following steps: S1, carrying out coordination self-assembly on a metal salt, an alkenyl pyridine ligand and an auxiliary ligand in a solvent, and washing and drying to obtain a coordination polymer single crystal reaction template; s2, under irradiation of ultraviolet light or visible light, the coordination polymer single-crystal reaction template is subjected to a [2 + 2] light ring addition reaction, and a coordination polymer containing a cyclobutane dimer is obtained; s3, under the action of alkali liquor or acid liquor, dissociating the coordination polymer containing the cyclobutane dimer, extracting, concentrating and recrystallizing to obtain dimer single crystals; s4, under the irradiation of ultraviolet light or visible light, carrying out topological chemical polymerization reaction on the dimer single crystal to obtain an organic polymer single crystal; accurate and controllable preparation from the alkenyl pyridine ligand to the high-quality polymer single crystal with the self-supporting long-range ordered structure is successfully realized.

A method for treating pruritus in patients with atopic dermatitis (AD) and / or nodular prurigo (PN) is disclosed, comprising administering a therapeutically effective amount of at least one compound selected from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-carbonyl]-4-methyl-4-[4-(oxecyclobutane-3-yl)piperazin-1-yl]pent-2-enonitrile (rezabrutinib) and pharmaceutically acceptable salts thereof.

The present invention relates to a process for producing trifluoroethylene in a reactor provided with a fixed catalytic bed comprising a catalyst, said process comprising a step a) of reacting a composition A comprising chlorotrifluoroethylene with hydrogen in the presence of a catalyst and in the gas phase to produce a stream B comprising trifluoroethylene, characterized in that said composition A also comprises at least one of the additional compounds C1 chosen from the group consisting of 1,1,1-trifluoroethane, 1,1,1,2-tetrafluoroethane, hexafluorocyclobutene, fluoroethane, 2-chloro-1,1,1-trifluoroethane, 1,2-dichlorohexafluorocyclobutane. The present invention also relates to a chlorotrifluoroethylene composition.

The invention discloses a synthetic method of a 3-spirobutyl oxoindole compound containing trifluoromethyl, and belongs to the technical field of organic synthesis. According to the invention, under the action of visible light induction, a photocatalyst and alkali, CF3Br and N-aryl bicyclo [1.1. 0] butane-1-formamide are subjected to a free radical tandem cyclization reaction in an organic solvent, so that the 3-spirobutyl oxoindole compound containing trifluoromethyl is prepared. According to the invention, free radical series cyclization reaction of CF3Br and saturated carbon atoms, namely sp3 hybrid carbon atoms, is realized for the first time, and the variety of organic matters reacting with CF3Br is enriched. The preparation method provided by the invention provides a new path for synthesis of 3-spirobutyl oxindole containing trifluoromethyl, has the advantages of cheap and easily available raw materials, mild reaction conditions, simple operation, high product yield and the like, and accords with the concept of green synthesis.

Provided herein are methods of using 2-(2,6-dioxopiperidin-3yl)-4-(2-fluoro-4-(3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione, or an enantiometer, a mixture of enantiomers, a tautomer, an isotopolog, or a pharmaceutically acceptable salt thereof, alone or in combination with obinutuzumab, for treating, preventing or managing chronic lymphocytic leukemia / small lymphocytic lymphoma.

This invention relates to a method for preparing a bimetallic cyanide (DMC) catalyst, comprising a reaction of an aqueous solution of a cyanide-free metal salt, an aqueous solution of a basic metal cyanide salt, an organic complexing ligand, and optionally a component forming a complex, wherein the metal cyanide salt is one or more compounds selected from potassium hexacyanocobalt(III), potassium hexacyanoferrate(II), potassium hexacyanoferrate(III), calcium hexacyanocobalt(III), and lithium hexacyanocobalt(III), wherein the organic complexing ligand is one or more compounds selected from dimethoxyethane, tert-butanol, 2-methyl-3-buten-2-ol, 2-methyl-3-butyn-2-ol, ethylene glycol mono-tert-butyl ether, and 3-methyl-3-oxetane-methanol, and wherein the basic metal cyanide salt used has an alkalinity between 0.700 wt% and 3.000 wt% sodium hydroxide (NaOH) based on the total weight of the basic metal cyanide salt used, determined by titration as disclosed in the experimental section. Another subject of the invention includes a bimetallic cyanide catalyst (DMC) obtainable by the method according to the invention, and the use of said DMC catalyst in the preparation of polyoxyethylene polyols.

To provide a method for producing hexafluoropropene in which the formation of octafluorocyclobutane, a by-product, is suppressed, and a composition obtained by the said production method. [Solution] A method for producing hexafluoropropene, comprising preheating trifluoromethane at a first preheating temperature of 350 to 700°C, then contacting it with tetrafluoroethylene to obtain a product containing hexafluoropropene.