The invention relates to a generalized force-loading multidimensional fore-measuring bench calibration device and calibration method. The calibration device comprises a main calibration bench frame, a multi-dimensional force-measuring bench, a force applying mechanism, a first steel cable, a second steel cable and a sensing device. The main calibration bench frame is in an L shape; the multi-dimensional force-measuring bench is fixed at one side of the main calibration bench frame and a loading point is arranged; and the loading point, the first steel cable, the sensing device, the second steel cable and the force applying mechanism are connected successively. The force applying mechanism fixedly connected with the other side of the main calibration bench frame consists of a brake valve hand wheel, a first bidirectional screw rod, a connecting sleeve, a second bidirectional screw rod and a traction box, wherein the brake valve hand wheel, the first bidirectional screw rod, the connecting sleeve, the second bidirectional screw rod and the traction box are connected successively from top to bottom. The first bidirectional screw rod is provided with a fixed plate; and one end, in an inverted L shape of the fixed plate is connected with the main calibration bench frame fixedly and the other end is arranged by corresponding to the traction box. And a groove is formed in the bottom of the traction box and a traction sliding rod is arranged. According to the invention, forces and moments at multiple directions can be applied; and continuous vector force loading also can be realized, so that the error can be effectively reduced.