The invention discloses a solid-containing organic waste treatment and separation system based on supercritical water oxidation technology, including a solid-containing waste pretreatment module, a solid-containing waste preheating module, an oxidant supply module, a supercritical water oxidation module, and subsequent products Temperature and pressure reduction module, subsequent product online separation module. Through screw conveyors, crushers, vibrating screens, iron removers, grinding pumps and other devices, solid wastes are crushed, screened, and ground in multiple stages to meet the requirements of supercritical water oxidation feed. At the same time, by adding quartz sand to grind the sedimentary salt that may be generated in the system, the problems of salt deposition and blockage in heat exchangers, reactors and other equipment are avoided. For the gas-liquid-solid three-phase products after the reaction, a two-stage separation measure combining a three-phase separator and a liquid-solid two-phase separator is adopted. At the same time, the liquid phase separated by the liquid-solid separator is circulated and separated, which improves the liquid-solid separation. At the same time, the solid residue after the reaction can be used for brick making, ceramsite making and external sales, etc., which improves the system economy.