The invention provides a two-dimensional wind-induced vibration coefficient calculation method for an ultra-standard oversized cooling tower. The method comprises the steps of a, building a geometric model, wherein the full-size geometric model of the cooling tower and a computational domain of a flow field where the cooling tower is located are built based on the actual size of the cooling tower; b, mesh generation, wherein the computational domain is divided into grids by means of the local cipher technique; c, numerical simulation computation, wherein a turbulence model is selected, boundary conditions are set, and numerical wind tunnel simulation analysis is conducted to obtain tower tube outer surface wind pressure time interval; d, solving wind-induced response, wherein a finite element model of the cooling tower is built, and wind-induced dynamic response of the cooling tower is analyzed; e, computing a wind-induced vibration coefficient, wherein the tower tube two-dimensional wind-induced vibration coefficient is computed based on structural response time interval; f, analysis fitting, wherein fitting of the tower tube wind-induced vibration coefficient is conducted based on a nonlinear least square principle, and finally a two-dimensional wind-induced vibration coefficient fitting formula is provided.