The present invention relates to the field of grape wine, and in particular relates to a medicinal-edible homologous traditional Chinese medicine composition and use thereof and grape wine and a preparation method of the grape wine, and the medicinal-edible homologous traditional Chinese medicine composition includes Chinese wolfberry, poria cocos, chrysanthemum, polygonatum, cinnamon and alpinia oxyphylla. The medicinal-edible homologous traditional Chinese medicine composition has the effects of tonifying kidney, reinforcing essence and blood, resisting fatigue, nourishing liver and kidney, strengthening bones and muscles, softening blood vessels, beautifying, nourishing face, enhancing immunity, and delaying senescence. The grape wine not only keeps the original grape wine mellow, fragrant and rich taste, also has the effects of tonifying kidney, reinforcing essence and blood, resisting fatigue, nourishing liver and kidney, strengthening bones and muscles, softening blood vessels, beautifying, nourishing face, enhancing immunity, and delaying senescence.