The invention discloses a computer hardware fixed protection device. The device comprises a hardware box and a base arranged in the hardware box body. The base is provided with a slide rail, a slider,a vertical column, a clamping block, a tooth strip, an adjusting tooth, a limiting plate, a spring supporting plate, a spring, and a hardware mounting plate; one side of the hardware box is hinged with a box cover, and the box cover is provided with two corner buckles symmetrically. The hardware box body is provided with a locking groove, a locking block, a pull rod and a handle; and the hardwarebox is provided with a fan. The fixed protection device is provided with a fixed clamping mechanism, which can fasten all the hardware to the hardware installation board, thereby effectively preventing the hardware from being loose due to long-term work or external vibration. The fixed holding device is arranged as a closed cavity to prevent dust from entering the hardware, avoiding hardware damage and ensuring the running speed of the computer. The cooling fan is also arranged to cool down the hardware to prevent the hardware from being damaged due to a large amount of heat, prolonging the service life of the hardware, and keeping it new.