The present invention discloses highly active SOD enriched compound vitamin buccal tablets and a preparation method thereof. The buccal tablets are prepared from the following components in parts by weight: 1 part of superoxide dismutase, 0.2-0.3 part of sialic acid, 3-4 parts of hydroxypropyl-beta-cyclodextrin, 12-15 parts of collagen liquid, 30-40 parts of sugarcane juice, 15-30 parts of starch and 50-70 parts of compound vitamins. The superoxide dismutase, and sugars (sucrose, glucose, fructose, etc.), amino acids, vitamins, etc. rich in the sugarcane juice are clathrated together with the hydroxypropyl-beta-cyclodextrin, and an encapsulation effect of the collagen is combined, so that the buccal tablets can effectively improve a stability of SOD and can maintain a relatively high activity for a long time. A small amount of the sialic acid is added and nutrients of the sugars, amino acids, vitamins, etc. rich in the sugarcane juice are supplemented, so that the buccal tablets can play synergistic effects and enhance oxidation resistance of the superoxide dismutase.