In a process for producing a biocompatible 
stent, a tubular substrate of the 
stent adapted for diametric expansion has a layer of a 
noble metal oxide formed over at least the outer surface of greater 
diameter of the substrate, the substrate being composed of a 
metal or an 
alloy thereof that is non-noble or less-noble than the layer's 
noble metal. An interface region adapted to prevent 
corrosion and to provide a firm bond between the surface of the substrate and the 
noble metal oxide layer is established, at least in part, by forming the noble 
metal oxide layer with a progressively varying concentration of noble 
metal-to-oxide with depth of the layer such that a surface of pure noble metal and negligible oxide of the layer is in closest proximity to the surface of the substrate. In one embodiment of the process, the interface region is established by forming the surface of pure noble metal and negligible oxide thereof in direct contact with the metal or 
alloy of the 
substrate surface. In another, the interface region is established by first creating an oxide of the substrate metal or 
alloy thereof at the 
substrate surface, and then forming the noble metal oxide layer as above, but in contact with the substrate metal or alloy oxide. Alternatively, the noble metal oxide layer has no progressively varying concentration but simply overlies an oxide of the substrate metal or alloy.