The invention discloses a cultivation formula material of ter-mitomycesHeim with reed residues as a main formula material, a making method of the cultivation formula material and a cultivation methodof the ter-mitomycesHeim. The cultivation formula material is prepared from 35-45% of the reed residues, 15-20% of wheat bran, 20-25% of wood dust, 1-5% of soybean meal, 8-14% of corncobs, 2-6% of corn flour and lime powder or light calcium carbonate for pH adjustment. The making and cultivation methods comprise the steps of firstly, pre-wetting the main formula material, then mixing auxiliary materials in the main formula material, uniformly mixing the materials, adjusting the pH, conducting bagging and high-pressure sterilization, after cooling, inoculating a ter-mitomycesHeim strain in a sterile environment, culturing the strain at 22-26 DEG C until the strain is grown full of hyphae, and after 30 days, conducting fruiting through earthing. According to the cultivation formula material,the cultivation flow process of existing ter-mitomycesHeim is not changed, only the formula is adjusted properly, and a nutrition solution is sprayed after earthing, so that the yield is increased; the reed residues are utilized for replacing part of existing main cultivation materials, so that a great cultivation effect is obtained, the utilization rate of the reed residues is increased, the formula cost is significantly reduced, and the biological conversion rate of the ter-mitomycesHeim is increased.