The present invention relates to the technical field of taping machines, and discloses an automatic vertical numerically-controlled wire taping machine. The automatic vertical numerically-controlled wire taping machine comprises a frame, wherein the frame is sequentially provided with a wire incoming roller set, a first tape rotating device, a first tape storage mechanism, a wire leading mechanism and an unwinding wheel along a wire incoming direction, the first tape rotating device is provided with a containing cavity for containing tape rolls, the containing cavity is provided with an upper end cover which can be detachably connected, and the first tape storage mechanism is provided with a limiting component which is used for limiting stored tape rolls from moving down; and the frame is also provided with a control device which is used for controlling the wire leading mechanism and the first tape rotating device. When the taping machine works, the tape rolls placed in the containing cavity are firstly used, and if the current tape rolls are completely used, new tape rolls can be directly put in the containing cavity from the first tape storage mechanism, wires are in wireless disconnection, tapes can be directly replaced, and thus the labor intensity of operators can be reduced, the taping efficiency can also be increased, a plurality of equipment can be guarded by a single person, and the labor can be reduced.