The invention provides a low-noise high-shielding fA-level current signal cable for a radiation environment and a manufacturing process. The cable comprises an inner conductor arranged in the center of the cable, and a wrapping insulating layer, a wrapping semi-conductive layer, an outer conductor, an inner sheath, an outer shielding layer, a wave-absorbing functional layer and an outer sheath which sequentially wrap the outer layer of the inner conductor. According to the technical scheme, the cable has excellent strength, tensile capacity and ideal flexibility, can meet the requirements of low noise, high shielding, high temperature resistance, good flame retardance, radiation resistance and the like required by a radiation environment, and is suitable for stable and high-precision transmission of fA-level weak current signals.