The invention belongs to the technical field of PVC plastic plates, and particularly relates to a high-strength environment-friendly PVC antibacterial plate and a preparation method thereof. The PVC antibacterial plate comprises the following raw materials: PVC resin powder, a plasticizing accelerator, a reinforcing agent, a filling agent, wood flour, an antibacterial agent, a stabilizer, a lubricant, a delustering agent and an ink absorbing agent. According to the high-strength environment-friendly PVC antibacterial plate, the compound reinforcing agent is added, so the obtained plate is highin hardness, high in strength and resistant to corrosion; a wood powder filler is added, so the density of the plate is reduced, and the plate is light in weight, good in rigidity and strong in woodtexture; the added stabilizer is green, environment-friendly and pollution-free; the specific delustering agent is added, so the surface of the manufactured plate is low in light reflection rate and soft in gloss, and such a matte effect can improve the comfort level of a light environment and allows people to not be prone to visual fatigue; and the plate surface has uniform and consistent gloss,and does not need secondary processing and painting, so cost is saved.