The invention provides a B-ultrasonography probe disinfecting device convenient to use. The device comprises a clamping beam unit, a dustproof case, a concave type frame, supporting foot stands, a disinfection box unit, a B-ultrasonography probe, a control box and a disinfectant storage case, wherein the clamping beam unit is installed on the upper portion of the dustproof case in a bolted mode, and the dustproof case is installed in the middle in the concave type frame in a bolted mode. By arranging a clamping beam body, a motor, a motor installation plate, an adjustable clamp rod unit, an installation wheel, a sliding rail and a B-ultrasonography probe chuck unit, the probe can be driven by the motor to rotate in all directions, so that the probe can be completely disinfected so as to be normally used in the later stage, and disinfection efficiency is improved. By arranging an adjustable clamp rod body, an installation groove, a probe clamping block, fastening screws and a rubber mat, the probe can be clamped quickly, clamping and cleaning of probes in different specifications can be achieved, using is more convenient, and application and popularization can be achieved easily.