An apparatus for chromatographic
interfacing includes an
interfacing unit, a sample acquisition unit, and a sample
trapping unit. The
interfacing unit includes (i) a chromatographic inflow valve adapted to receive a chromatographic sample separation flow, (ii) a chromatographic outflow valve adapted to allow
discharge of the sample separation flow, (iii) a loop expulsion inflow valve adapted to receive an expulsion fluid flow, and (iv) a loop expulsion outflow valve in fluid communication with the loop expulsion inflow valve and adapted to allow
discharge of a fluid. The sample acquisition unit includes (i) an inflow selector in selectable fluid communication with the chromatographic inflow valve or the loop expulsion
inlet valve, (ii) an outflow selector in fluid communication with the loop expulsion outflow valve, and (iii) one or more collection loops, each loop being independently selectable to establish fluid communication between the inflow selector valve and the outflow selector valve. The sample
trapping unit includes (i) a trap in selectable fluid communication with the loop expulsion outflow valve and defining a flow path from a first port to a second port and through a
stationary phase disposed therebetween, the
stationary phase adapted to trap an
analyte of interest from a fraction of the chromatographic sample separation flow, and (ii) a
scavenging gas source in selectable fluid communication with the flow path and a vacuum source in selectable fluid communication with the flow path, the
scavenging gas source and vacuum source adapted to substantially dry the
stationary phase.