The invention belongs to the technical field of
biology, and particularly relates to a Caierin 1.1 polypeptide containing a 131I
label and an application of the Caierin 1.1 polypeptide. The 131I-labeled Caerin 1.1 polypeptide provided by the invention is labeled by adopting a
chloramine-T
iodine direct labeling method, and the method has high labeling rate and strong stability. According to the 131I-labeled Caerin 1.1 polypeptide provided by the invention, the characteristic that a Caerin 1.1 polypeptide has specificity, enters a tumor
cell through membrane
receptor binding, and can inhibit growth and proliferation of the tumor
cell is adopted; and after 131I-Caerin 1.1 specifically enters the tumor
cell, the 131I-labeled Caerin 1.1 polypeptide can be used for emitting gamma rays and for
tumor imaging, and the 131I can be used to emit beta rays for intra-tumor
irradiation treatment, so that integration of tumor diagnosis and treatment and
visualization of a tumor treatment process arerealized, the tumor
treatment effect is improved, and tumor diagnosis and treatment cost are reduced.