10 results about "Perfusion rate" patented technology

A computing system may predict a complication based on measurements of related biomarker(s) obtained via one or more sensing systems, and generate an adjustment of a surgical parameter associated with a surgery. The biomarker measurements may include pre-surgical and / or in-surgical measurements. The hemostasis-related biomarker(s) measured pre-surgery may include blood pressure, blood pH, edema, heart rate, blood perfusion rate, coagulation status and / or the like. Based on the prediction, the computing system may generate a control signal configured to alter a matter in which a surgical cutting and stapling device and / or a surgical energy operate, to adjust a surgical procedure plan, to adjust to a surgical instrument selection, indicate a probability of the hemostasis complication, and / or to indicate a suggested adjustment to surgical procedure plan, surgical approach, and / or surgical instrument selection.

The invention discloses a therapeutic instrument temperature real-time monitoring method based on an intelligent sensor. According to the method, a personalized finite element model is constructed by collecting a three-dimensional medical image and real-time sensing data of a patient; forward calculating a theoretical three-dimensional temperature field based on a biological heat transfer model; fusing and correcting the theoretical temperature field and the real-time treatment parameters by using a data assimilation algorithm to obtain an accurate real-time three-dimensional temperature field and a corrected blood perfusion rate; on this basis, the system further calculates a three-dimensional thermal dose field, carries out risk assessment in combination with a real-time temperature field, and finally generates a predictive alarm and closed-loop control instruction; the method has the core advantages that a physical model and sparse sensing data are deeply fused, a digital thermal field model synchronous with physiological characteristics of a patient is constructed, crossing from point temperature measurement to body monitoring is achieved, temperature distribution of a whole treatment area can be comprehensively and accurately predicted in real time, and a monitoring blind area is eliminated.

This invention discloses a COMSOL-based method and system for dynamic simulation of the three-dimensional temperature field in microwave liposuction. The method comprises: Step 1, constructing a three-dimensional geometric model of the skin tissue-microwave liposuction antenna coupling system; Step 2, establishing a multi-physics coupling model, including bidirectional coupling of the electromagnetic wave-frequency domain physical field and the biological heat transfer physical field; Step 3, setting dynamic coupling boundary conditions, calculating and updating the blood perfusion rate in real time based on the current tissue temperature, and feeding it back to the heat transfer calculation in the next time step, thereby realizing the dynamic feedback coupling of electromagnetic heat generation and the temperature field; Step 4, using a transient fully coupled solver to jointly solve the electromagnetic wave-frequency domain physical field and the biological heat transfer physical field to obtain the spatiotemporal distribution data of the three-dimensional temperature field of the skin tissue during microwave liposuction. This invention achieves accurate simulation of the microwave liposuction process by introducing dynamic physiological parameters and bidirectional multi-physics coupling.

The invention belongs to the technical field of obstetrical nursing, and particularly relates to an obstetrical nursing abdominal pressure device which comprises a bed. Through the design of the adjusting mechanism and the linkage of components such as a gear and a gear ring, a first rectangular rack is driven to move in a first sliding groove in the radial direction, precise adjustment of the pressing point range is achieved, and the defect that a traditional abdominal pressure device is cut at a time is overcome for patients with different body types; through the design of the vibration mechanism and the mechanical transmission of the eccentric turntable, the push rod and other components, the generated resonant frequency enables the uterine muscle layer to generate periodic micro-vibration, so that the blood perfusion rate can be increased, and the removal of metabolic wastes can be accelerated; through the design of a pressing mechanism, meshing of a worm and a worm gear and precise driving of a third stepping motor, rotary motion is converted into linear displacement of a second rectangular rack, and through the linkage design of a spring and a pressure sensor, the defects that air bag type adjustment depends on air pump pressure and is prone to being affected by temperature are overcome; according to the design, more stable pressure application control is realized through rigid mechanical transmission.

The invention discloses a perfusion culture method for increasing the upper limit of living cell density before seed transformation in a cell culture N-1 stage, and relates to the technical field of cell culture. The method comprises the following steps: supplementing a basic culture medium on the 3rd day of wave culture, carrying out gradient increasing perfusion by using the basic culture medium at different perfusion rates every day from the 5th day, monitoring pH and DO parameters every day, enabling cells to be in a high-density and high-motility growth state, removing the waste culture medium through a cell interception membrane in a disposable wave perfusion bag, and finally obtaining the high-density and high-motility cells. The cells are retained in the culture bag, and the living cell density upper limit before seed transformation is improved. According to the method, a culture mode of supplementing materials and then performing perfusion is adopted, so that 200L and 500L reactor processes in a common culture process are omitted, a 2000L reactor can be directly connected for culture after a wave process, and the time and the cost of a cell culture process are saved.

This invention discloses an automated peritoneal dialysis method based on blood pressure fluctuations, comprising: real-time acquisition of blood pressure and physiological signals, intra-abdominal pressure signals, perfusion volume, and perfusion rate; preprocessing and time-series alignment of these signals to extract state feature vectors for the peritoneal dialysis perfusion stage; inputting the state feature vectors of the perfusion stage into several pre-trained blood pressure prediction models to obtain multiple predicted blood pressure change trends and risk levels; calculating model reliability indices and divergence based on the predicted blood pressure change trends; if the model divergence exceeds a divergence threshold, combining the reliability indices with weighted fusion of multiple predicted blood pressure change trends to obtain credible predicted blood pressure change trends and their risk levels; and generating perfusion control parameters within a target time window of the perfusion stage, with blood pressure stability and smooth intra-abdominal pressure changes as optimization objectives, based on the credible predicted blood pressure change trends and their risk levels.

The application relates to an endometriosis organoid intelligent monitoring method, system, device and medium method and system. The method comprises the following steps: acquiring bright field images of an experimental culture cavity and a reference culture cavity in a microfluidic double-chamber, acquiring temperature sensing data and pH sensing data of the two chambers; inputting a lightweight convolutional neural network for foreground segmentation to obtain organoid segmentation masks of the two chambers; extracting morphological features based on the segmentation masks to identify invasive phenotypes, and obtaining invasive indexes and invasive phenotype labels of the two chambers; combining the segmentation masks and the pH sensing data to calculate a target perfusion rate; driving a microfluidic perfusion system to regulate the flow rate, performing temperature proportional integral differential control according to the temperature sensing data to generate temperature regulation state data; and integrating the above data to generate an endometriosis organoid intelligent monitoring result. The method can realize intelligent monitoring and closed-loop regulation of the culture environment of endometriosis organoids, and improve the accuracy and experimental efficiency of organoid invasiveness evaluation.

The invention discloses a perfusion culture method and application of CHO (Chinese hamster ovary) cells. The perfusion culture method comprises the following steps: inoculating CHO cells, and carrying out cell amplification culture; when the cell density reaches 6 * 10 < 6 > / mL to 10 * 10 < 6 > / mL, perfusion is started, the perfusion rate is 0.5 VVD to 1 VVD, and the perfusion rate is adjusted according to a constant proportion based on the cell density until the cell density reaches 90 * 10 < 6 > / mL to 120 * 10 < 6 > / mL, and the constant proportion is 1 VVD / (33 * 10 < 6 > / mL to 37 * 10 < 6 > / mL); and when the cell density reaches 90 * 10 < 6 > / mL to 120 * 10 < 6 > / mL, cooling and releasing are carried out at the same time, and the cell density is maintained. According to the perfusion culture method, high-density culture of CHO cells is realized, the culture time is greatly prolonged, and the duration for maintaining high cell viability is greatly prolonged.

The invention belongs to the field of liver zoning organs, and provides a liver zoning organ chip with physiological oxygen concentration gradient, a system and a method.The liver zoning organ chip comprises an oxygen barrier layer, a perfusion layer, a culture layer and an electrode layer, the oxygen barrier layer is arranged at the topmost end, and the perfusion layer and the culture layer are composed of PDMS and used for oxygen-containing culture solution perfusion and cell culture respectively; the two layers are separated through a porous membrane; the electrode layer is provided with a vacuum sputtering electrode detection system for detecting glutamic-pyruvic transaminase released by cells, and the glutamic-pyruvic transaminase flows through the winding channel from the cell culture area to enter the detection cavity; by controlling the perfusion speed of the oxygen-containing culture solution, an adjustable physiological oxygen concentration gradient interval is formed. According to the invention, through strategies of convection, diffusion and consumption of environmental oxygen, the permeation effect and the blood flow field of a hepatic sinus window hole are simulated, and a controllable oxygen concentration gradient close to an in-vivo hepatic cell microenvironment is realized.

An electronic device may include: a first temperature sensor configured to measure a first temperature of a skin surface when a user comes into contact with a main body of the electronic device; a first heating element spaced apart from the first temperature sensor by a first predetermined distance; a second temperature sensor spaced apart from the first heating element by a second predetermined distance and configured to measure a second temperature inside the main body; and a processor configured to: estimate heat flux based on the first temperature and the second temperature; estimate a blood perfusion rate of the user based on a temperature of the first heating element and the first temperature, and estimate a core body temperature of a user based on the first temperature, the estimated heat flux, and the estimated blood perfusion rate.