The invention discloses an anti-disease health-care beverage and a preparation method thereof, relates to a non-alcohol beverage, and also relates to medicine preparation. The invention aims to provide a medicine-type beverage capable of quenching thirst and preventing some diseases and a manufacturing method thereof. The beverage of the present invention is prepared from 18 traditional Chinese medicines including tendrilleaf fritillary bulbs, pseudo-ginseng, golden thread, epimedium herb, giant knotweed rhizomes, rhubarb roots and rhizomes, Chinese gall, lightyellow sophora roots, platycodonroots, peppermint, milkvetch roots, broadleaf holly leaves, phellodendron bark, ganoderma lucidum, christina loosestrife, gynostemma pentaphyllum, lotus leaves and gingko nuts, and is prepared by crushing the above medicines, soaking the medicines in boiling water according to a formula ratio, and adding a preservative. The thick juice of the beverage, as a medicine, has the efficacy of clearing away heat, expelling toxins, relieving cough, reducing phlegm, lowering blood pressure and blood lipid, resisting cancers and resisting aging, and can prevent infectious diseases such as atypical pneumonia, AIDS and typhoid fever.