The present invention is directed to a multi-organ-
chip device comprising a base layer; an organ layer arranged on the base layer; an antra layer arranged on the organ layer; and an
actuator layer; wherein the base layer is configured to provide a
solid support for the further
layers; the organ layer is configured to comprise a multiplicity of individual organ equivalents, each organ equivalent comprising one or more organ growth sections, each of the organ growth sections being configured to comprise an
organoid cavity for housing at least one
organoid of an organ and to comprise a micro-inlet and a micro-outlet for fluid communication between the
organoid cavity of the organ growth section and a self-contained circulation
system, wherein the organ layer comprises at least one organ equivalent configured to represent the organs
lung,
small intestine,
spleen,
pancreas, liver,
kidney and
bone marrow, respectively, and a self-contained circulation
system configured to be in direct fluid communication with the organ growth sections of the organ layer via the micro inlets and outlets of the organ growth sections; the antra layer is configured to comprise a multiplicity of cavities and tubes arranged to be in fluid communication with selected organ equivalents or organ growth sections in order to allow for exchange of fluids between cavities and organ growth sections; and the
actuator layer is configured to comprise a multiplicity of actuators arranged and configured to regulate a pressure force applied on a selected organ equivalent, the self-contained circulation
system and / or part thereof.