The invention relates to a heparin sodium purification technology. The crude heparin sodium purification technology sequentially comprises the following steps: 1, dissolving crude heparin sodium in a sodium chloride solution, and adding an alkaline protease for enzymatic hydrolysis; 2, inactivating, adding diatomite, carrying out high speed centrifugation, and removing insoluble impurities; 3, adding polysilicate, carrying out high speed centrifugation, and removing insoluble impurities; 4, adding alcohol for precipitating, and removing supernatant alcohol; 5, dissolving in the sodium chloride solution, adding hydrogen peroxide for oxidizing, carrying out high speed centrifugation after oxidation, and removing insoluble impurities; 6, adding alcohol for precipitating, and removing supernatant alcohol; and 7, filtering, and carrying out vacuum lyophilizing to obtain refined heparin sodium. The crude heparin sodium purification technology has the advantages of low content of proteins in the refined heparin sodium, and high yield of the refined heparin sodium.