The invention discloses a paranasal sinus drainage retention device which comprises a retention tube and a puncture needle, wherein the puncture needle is arranged in the retention tube and penetrates through the retention tube; when the paranasal sinus drainage retention device is used, a puncture needle head is punctured into a nasal cavity of a patient, the puncture needle is pulled out after the puncture needle head arrives a designated spot, a plug is closed, an injector is inserted into a first check valve, proper amount of air is introduced according to the condition of the patient, then the injector is pulled out, an air bag swells, the retention tube is fixed in the nasal cavity, the injector is inserted into a second check valve, a cleaning liquid or medicine is injected into the nasal cavity through a washing tube and a sleeve tube, and the injector is pulled out after completion. The paranasal sinus drainage retention device is simple in structure, convenient to operate, safe and reliable, and can retain in a nose for a long period of time after puncture once, retention is realized under local anesthesia after puncture once, the effects of washing and injecting the medicine are achieved, the harm caused by unnecessary general anesthesia and repeated punctures on the patient is avoided, the infection risk caused by the repeated punctures is also reduced, and a sinus cavity is directly and accurately washed with the medicine.