The invention discloses an automatic calibration programmable instrumentation amplifier for sensor signal processing. A multiplexer T1, a multiplexer T2, a multiplexer T3, a multiplexer T4, an automatic calibration amplifier A1, an automatic calibration amplifier A2, a resistor R1, a resistor R2, a resistor R3, a resistor R4, a resistor R5, a resistor R6, a resistor R7, an instrument amplifier A3, an output amplifier A4, an output amplifier A5, an AB-class amplifier A6, an AB-class amplifier A7 and an amplifier A8 are matched and connected with one another, so that the sensitivity of the sensor can be effectively improved; and the non-ideal characteristic of the sensor and the imbalance, range and drift of the sensor are eliminated, the instrumentation amplifier which is capable of automatic calibration, low in noise, low in linear error, low in imbalance drift and programmable in gain is manufactured, the use effect of the sensor signal processing automatic calibration programmable instrumentation amplifier is better, and the user experience feeling is better.