2 results about "Body Patterning" patented technology

Chronic wounds are characterized by a persistent hyperinflammatory environment that inhibits progression toward regenerative wound closure. Such chronic wounds are particularly prevalent in diabetic patients, often necessitating distal limb amputation, but they also occur in non-diabetic and elderly patients. Inducible expression of HoxA3, a homeobox family member and master regulatory transcription factor for body patterning, has been shown to promote wound closure in diabetic mice when administered topically as a plasmid encapsulated in a hydrogel. Here, we provide independent reproducibility of basal in vivo studies of diabetic wound closure and further expand on these studies while minimizing the estimated minimum dose threshold. Furthermore, we observed similarities in spontaneous wound healing rates between non-diabetic aged mice and diabetic young mice, which motivated us to test the topical application of HoxA3 plasmids in non-diabetic aged mice, where accelerated wound healing was also observed. In these short studies, no significant adverse effects were observed macroscopically or by local histology. Local administration of HoxA3, either as a plasmid or as a future alternative therapy, is a noteworthy translational option for chronic wounds.

Issue:  Making available pajamas whereby a wearer's muscles and body can be taken care of when the wearer is lying down / sleeping.Resolution Means:  Pajamas 100 of the present invention comprise a main upper-body part 10 and a main lower-body part 20, wherein the main lower-body part 20 is formed with first lower-body patterning features 51 that are positioned in locations following the tensor fasciae latae muscles (81), and with second lower-body patterning features 52 that are positioned in locations following at least either the semitendinosus muscles (85) or the semimembranosus muscles (86).  On the back side (19) of the main upper-body part 10, an S-shaped upper-body patterning feature 55 is formed.  The upper-body patterning feature 55 is constituted from: a first back-side patterning 55a that extends from the upper right to the lower left; a second back-side patterning 55b that starts from the lower end 71 of the first back-side patterning 55a and extends from the upper left to the lower right; and a third back-side patterning 55c that starts from the lower end 72 of the second back-side patterning 55b and extends from the upper right to the lower left.