The present invention discloses a nickel-base high-temperature alloy/titanium alloy composite material for aero-engine. The material comprises the following three layers of metal materials: a nickel-base high-temperature alloy plate (2) on the upper layer, a nickel-base high-temperature alloy plate (5) on the lower layer and a titanium alloy plate (4) in the middle layer, wherein the material trademark of the titanium alloy is Ti-6Al-4V, the chemical components of the titanium alloy comprise 5.5-6.75% of aluminum, 3.5-4.5% of vanadium, and the balance of titanium, the material trademark of the nickel-base alloy is K4169, and the chemical components of the nickel-base alloy comprise 0.5% of aluminum, 0.05% of zirconium, 1.0% of titanium, 3.0% of manganese, 5.2% of niobium, 18.5% of chromium, 52% of nickel, 3.0% of molybdenum, 0.05% of carbon, and the balance of iron. According to the present invention, the bonding rate of the composite material achieves 100% and achieves metallurgical bonding, the nickel-base high-temperature alloy has characteristics of high temperature ablation resistance and high high-temperature strength, and can be used for a long time at a high temperature, the titanium alloy can provide a structure support effect, and the composite material has characteristics of light weight, high temperature resistance and high strength, and is a novel aircraft engine composite material with characteristics of light weight, high strength and high temperature resistance.