The invention provides a toothpaste formula. The toothpaste formula comprises, by weight, 30-40% of glycerin, 15-20% of propylene glycol, 14-18% of calcium hydrogen phosphate, 0.1-0.2% of carrageenan,0.2-0.3% of agar, 0.6-1.0% of sodium carboxymethyl cellulose, 1-2% of a foaming agent, 1-3% of pullulan, 4-7% of xylitol, 1-2% of vervain extract and 3-5% of a cooling composition. The cooling composition is composed of (1R,2S,5R)-N-(4-(cyanomethyl)phenyl)-2-isopropyl-5-methyl cyclohexane methanamide, methanamide and glycerin triacetate. By component selection and compounding and cooperative interaction of components, prepared toothpaste is safe, mild, nonirritant, moderate in friction, great in glycerin triacetate, smooth, delicate and effective in cooling, has anti-inflammation and bactericidal functions and has excellent efficacies in dental and oral health protection.