The invention discloses a large-section-height multi-row micro-difference extrusion blasting method. A vertical deep hole is adopted as a blast hole, hole distribution is conducted according to the principle that explosive is evenly distributed in a to-be-blasted rock body, and the hole distribution manner is a rectangular hole distribution manner. Through determination on blasting parameters, anexplosive filling structure is designed, the multi-hole rowed hole distribution manner is selected on the vertical plane, a deflection center point is selected as a blasting point, and micro-difference sequential blasting is adopted between the adjacent holes and is adopted in holes between rows. The large-section-height multi-row micro-difference extrusion blasting method has the beneficial effects that a favorable free face is created for subsequent ore body rock blasting, and the rock clamping action is lowered; in the rock block motion process after rock body crushing, rock blocks are mutually in collision, mutual rubbing happens, impact pressure and shearing force are generated, the rock blocks are crushed again, a rock block diameter reducing blasting method is provided, the blastedrock body crushing degree can be improved, the blasting vibration effect is reduced, harm to ground buildings is lowered, and mine safety is maintained.