The invention relates to the technical field related to tunnel driving equipment, in particular to a grouting structure in the tunnel driving process and a grouting method matched with the grouting structure. The grouting structure in the tunnel driving process and the grouting method aim at solving the problem that in the prior art, filling a gap in the back portion of a segment cannot be achieved through synchronous grouting. The grouting structure in the tunnel driving process sequentially comprises a rock stratum and a segment stratum inwards from the inner wall of a tunnel, and accordingly a side-top arch, in unit of blocks, is formed. A support frame is arranged between the segment stratum and the rock stratum, and accordingly a hollow interlayer is formed. A base lining platform is arranged on the bottom of the side-top arch, and reserved grouting holes communicating with the hollow interlayer are formed in the positions, corresponding to the side-top arch blocks, of the top of the segment stratum. The reserved grouting holes are moveably connected with grouting pipes, and the other ends of the grouting pipes are connected with a grouting machine. The grouting structure in the tunnel driving process and the grouting method have the beneficial effects that the grouting cost is not increased, the grouting process is smooth, the utilization rate of the grout is high, the structure of equipment is simple, repairing and later maintenance are convenient, the assembling and disassembling time is short, grouting pressure can be monitored at any time, the grouting quality can be guaranteed, and a framework layer is formed on the contact surface between the grout and water glass so that flowing of the grout to a cutterhead can be reduced.