The invention discloses a steel-concrete combined box beam which comprises two steel webs, a steel bottom plate, a diaphragm plate, a concrete layer, multiple stiffening ribs and a steel top plate, wherein the two steel webs and the steel bottom plate form a box chamber; the diaphragm plate is horizontally arranged at the upper part in the box chamber to divide the box chamber into an upper box chamber and a lower box chamber; the concrete layer is filled in the upper box chamber; the multiple stiffening ribs are arranged on the bottom plate in the lower box chamber; and the steel top plate is horizontally arranged on the top surface of the upper box chamber. In the steel-concrete combined box beam disclosed by the invention, the concrete combined top plate composed of the steel top plate, the steel webs, the diaphragm plate and the concrete layer bears pressure, and the lower bottom plate and multiple stiffening ribs bear the tension; and the steel-concrete combined box beam has the characteristics of high bearing capacity, high rigidity, good integrity and the like, greatly improves the structural stability, can give full play to the performance of the materials, is convenient to transport and hoist, and has short construction period, high efficiency and obvious economic benefits. Moreover, through the box beam, the height of the cross section of the box beam can be reduced, and the bridge appears more concise and beautiful.