The invention discloses a comprehensive utilization system of a high-power diesel generating set and a boiler. The system comprises the diesel generating set, the boiler, a water storage tank, a steam header and a circulating pump, wherein the steam header is arranged at the output end of the boiler, the output end of the steam header is communicated with the water storage tank, the water storage tank is provided with a water temperature sensor and an intelligent controller electrically connected with the water temperature sensor, the intelligent controller is electrically connected with the diesel generating set, the circulating pump and the steam header in sequence, the diesel generating set, the water storage tank and the circulating pump are communicated in sequence to form a loop, and the circulating pump is arranged on a pipeline between the water outlet end of the water storage tank and the water inlet end of the diesel generating set. Hot water generated by the water storage tank can make the diesel generating set be ready to be started all the time, once the mains supply fails, the diesel generating set is started at once, the problem that the diesel generating set cannot be started easily is solved, the service life of the diesel generating set is greatly prolonged, and the optimal time for power utilization will not be missed.