The invention discloses a production method of a disease-resistant medicine for treating cucumber powdery mildew, comprising the following steps: A, material preparation: 27% high-fat membrane, 2% pyrimidine nucleoside agri cultural antibiotic, garlic extract, astragalus polysaccharide, baicalein, polyoxin, root of Chinese pulsatilla and dryopteris crasirhitom nakai are prepared; B, alcohol leaching of extracts of the root of Chinese pulsatilla and Cyrtomium Rhizome: the root of Chinese pulsatilla and Cyrtomium Rhizome are crushed, broken and washed; after air drying, the root of Chinese pulsatilla and Cyrtomium Rhizome are placed in a closed container; 60 wt% of an ethanol solution is added, the root of Chinese pulsatilla and Cyrtomium Rhizome are infiltrated and immersed for 18 hours and then are placed in a percolator; the percolator is a barrel structure, a cone is arranged at the bottom of the barrel structure, and switch equipment for dripping is disposed below the cone for extraction of medicinal materials; medicinal materials are uniformly placed in the barrel; an immersion fluid, water or wine, is added and drips slowly; a percolate is collected; and ethanol is heated and recovered to obtain an extract; and C, 27% high-fat membrane, 2% pyrimidine nucleoside agri cultural antibiotic, garlic extract, astragalus polysaccharide, baicalein and polyoxin are combined with the extract obtained from the step B, uniform stirring is carried out, and UV sterilization is conducted so as to obtain the disease-resistant medicine for treating cucumber powdery mildew. The medicine provided by the invention requires a simple composition ratio, is convenient to use and has a good effect of treating cucumber powdery mildew. Through tests, a liquid which accounts for 400-600 times the volume of the mixture has an obvious inactivation effect on fungi imperfecti Sphaerotheca powdery mildew, and has a good bactericidal effect.