72 results about "Isotopomers" patented technology

Methods are provided for close-range intraoperative, endoscopic and intravascular deflection and treatment of lesions, including tumors and non-malignant lesions. The methods use antibody fragments or subfragments labeled with isotopic and non-isotopic agents. Also provided are methods for detection and treatment of lesions with photodynamic agents and methods of treating lesions with a protein conjugated to an agent capable of being activated to emit Auger electron or other ionizing radiation. Compositions and kits useful in the above methods are also provided.

Method and apparatus for detecting, by absorption spectroscopy, an isotopic ratio of a sample, by passing first and second laser beams of different frequencies through the sample. Two IR absorption cells are used, a first containing a reference gas of known isotopic ratio and the second containing a sample of unknown isotopic ratio. An interlacer or reflective chopper may be used so that as the laser frequencies are scanned the absorption of the sample cell and the reference cell are detected alternately. This ensures that the apparatus is continuously calibrated and rejects the baseline noise when phase sensitive detection is used.

A method of determining an empirical formula of an analyte ion from a measured mass spectrum including a main peak and one or more isotope peaks. The method comprises comparing a relative isotopic intensity of the measured isotope peak to a calculated relative isotopic intensity of an isotopic ion of a proposed empirical formula and comparing a relative mass defect of the measured isotope peak to a calculated relative mass defect of the isotopic ion of the proposed empirical formula. The proposed empirical formula is identified as a potential candidate for the analyte ion based on these comparisons.

A process and an apparatus for isotope ratio analysis, the process having the following steps: performing a liquid chromatography process and thus providing an eluate which comprises at least one liquid carrier fluid and at least one analytes, collecting a portion of interest from the eluate, processing the eluate portion to form at least one gaseous conversion products of the analytes, and supplying the gaseous conversion products, especially with gaseous carrier fluid, to an isotope analyzer and determining the isotrope ratios.

The present invention describes double labelling reagents with both an isotopic and isobaric label component suitable for differentially labelling different - protein samples. After labelling of the individual protein samples, all samples are pooled. Peptides from the pooled samples are isolated and analysed by mass spectrometry for determining the relative concentration of each differentially double-labelled polypeptide.

The object of the present invention is to provide an oxygen isotope concentration method capable of concentrating the stable oxygen isotopes of 17O and 18O which can be carried out using a simple device configuration. The present invention relates to a method for concentrating an oxygen isotope in separated oxygen by irradiating ozone with light, selectively dissociating an isotopomer of ozone containing an oxygen isotope in its molecule into oxygen, followed by dissociating the ozone and separating the formed oxygen from the non-dissociated ozone. The basic configuration of the device is provided with an ozone formation unit 11 that forms ozone from raw material oxygen, an ozone separation unit 12 that separates ozone formed with said ozone generation unit and raw material oxygen, an ozone photodissociation unit 13 that radiates light of a specific wavelength onto the ozone separated by said ozone separation unit 12 and selectively dissociates ozone containing an oxygen isotope in its molecule into oxygen, and an oxygen separation unit that separates the oxygen formed by dissociating ozone in said ozone photodissociation unit 13 and non-dissociated ozone to concentrate the oxygen isotope in the oxygen. The present invention also relates to a method for concentrating an oxygen isotope comprising an ozone photodissociation step, in which light is radiated onto a rare gas-ozone mixed gas containing ozone and at least one type of rare gas selected from krypton, xenon and radon to selectively dissociate ozone containing a specific oxygen isotope in its molecule into oxygen, and an oxygen isotope concentration step, in which the oxygen separated from ozone in said ozone photodissociation step is separated from non-dissociated ozone and rare gas to concentrate the oxygen isotope present in the separated oxygen. An oxygen isotope may also be concentrated in a dissociation reaction product by irradiating a gas containing a peroxide selected from hydroperoxides, (di)alkyl peroxides, peroxyacids including peracids, (di)acyl peroxides, peroxy esters, peroxycarbonates, peroxydicarbonates, diperoxycarbonates, peroxalates, cyclic peroxides, ozonides and endoperoxides, nitrite esters and nitrate esters, and selectively dissociating a peroxide containing a specific oxygen isotope in its molecule.

The invention provides a mechanism for semi-quantitatively measuring individual isotopomer species of a molecule using gas chromatograph mass spectrometry. The method allows for semi-quantitatively tracking the movement of ions by measuring the individual isotopomer species of a molecule.

Provided herein are Aminopurine Compounds having the following structures wherein R1, R2, and R3 are as defined herein, composition comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma. Provided herein are compounds having the following formula (I) and pharmaceutically acceptable salts, tautomers, isotopologues, and stereoisomers thereof, wherein R1, R2 and R3 are as defined herein.

A vial closure device, a sample vial incorporating such a vial closure device, and certain methods of using such a vial and closure device. The vial and closure device are intended to contain a gaseous sample or a headspace gas present above a liquid or solid material, so that the gaseous sample or headspace gas can be conveniently analyzed, typically by means of an autosampler connected to an analytical instrument such as a mass spectrometer. Mass spectrometric methods of determining the isotopic concentration of hydrogen and oxygen comprised in aqueous samples contained in vials fitted with such closure devices are disclosed. The vial closure device comprises a hollow body member locatable in the mouth of a vial, and a first seal for making a substantially gas-tight seal between the exterior of said hollow body member and said vial. The hollow body member comprises an aperture and an aperture closing means for closing said aperture when required, and a second seal, through which a gas sampling means may be inserted. The aperture closing means is operable to open the aperture by the insertion of a gas sampling means through the second seal and is operable to close the aperture when the gas sampling means is withdrawn.

A stable isotopic identification comprising a mathematical or numerical array of concentrations of isotopes found in a batched product, said mathematical or numerical array being presented in a machine readable form and comparable to analytical results whereby the product can be distinguished from other similar products, said machine readable form also being indexed through stored product information. The stored product information may be displayed when desired. By the stable isotopic identification of the invention, a product may be securely traced through manufacturing of a product, marketing of a product and the use of a product.

The present invention aims at providing a method and apparatus for analyzing a mass spectrum on which multivalent ion peaks originating from a target compound appear, and calculating the mass of the target compound. First, each peak on the mass spectrum is analyzed to detect isotopic clusters, and the valence and the representative point (m / z value) of each isotopic cluster are obtained (S1 through S3). Since the range of the m / z value of the component which is added to or desorbed from the compound is limited, by using this factor, the isotopic clusters originating from the same compound are deduced. By combining the deduced isotopic clusters, the candidates for the m / z value of the added / desorbed component are deduced (S5). Among the plurality of selected candidates, clearly abnormal candidates are eliminated by using a plurality of conditions such as the degree of distribution of the m / z values and the similarity of the relative intensities of the representative points of the isotopic clusters (S6 through S9). The candidate having the smallest distribution of m / z values or the candidate having the highest similarity of the relative intensities of the representative points is finally selected. After the m / z value of the added / desorbed component is determined, the mass of the compound is calculated (S 10 through S16).

One aspect of the invention provides a system for treating wastestream, particularly a liquid or aqueous radwaste, for safe disposal and, in final processing, converting it into one or both forms including an aqueous form for safe discharge to the environment and a solidified form for safe disposal. Another aspect provides the capacity to employ a step where a specific target element strategy can be set up synchronizing sorbent substance choices and multiple recycle options to remove target substances from wastestream as a part of its Sorption or Powder Sorbent Isotopic Reduction step (II). Other steps cooperate with Sorption step (II) including Oxidation (I) to inactivate or destroy existing chelants, Solid-Liquid separation (III), and Selective Ion Exchange (IV) to deliver the wastestream to final processing. Still further aspects of the invention address the recovery and safe handling of substances such as C-14.

The invention provides mass spectrometry methods, compositions and systems which enable a unique platform for analyte quantitation accessing very high degrees of multiplexing and accurate quantification, particularly well-suited for a range of quantitative analysis for proteomics applications. Embodiments of the present methods and systems combine isotopic coding agents characterized by very small differences in molecular mass with mass spectrometry methods providing large resolving power to provide relative or absolute analyte quantification in a large number of samples.

A method for identification of the monoisotopic mass or a parameter correlated to the mass of the isotopes of the isotope distribution of at least one species of molecules contained in a sample and / or originated from a sample by at least an ionization process includes measuring a mass spectrum of the sample with a mass spectrometer, dividing at least one range of measured m / z values of the mass spectrum into fractions, assigning at least some of the fractions to one processor of several provided processors, deducing for each of the at least one species of molecules an isotope distribution of their ions having a specific charge z, deducing from at least one deduced isotope distribution the monoisotopic mass or a parameter correlated to the mass of the isotopes of the isotope distribution of the species of molecules.

The invention relates to heterocyclic compounds and the application thereof in medicine. Specifically, the invention discloses heterocyclic compounds as shown in formula I, or isotopically-labeled compounds thereof, or optical isomers, geometric isomers, tautomers or a mixture of isomers thereof, or medicinal salts thereof, or prodrugs thereof. The invention also relates to application of these compounds in medicine.

An irradiation target for the production of radioisotopes, comprising at least one plate defining a central opening and an elongated central member passing through the central opening of the at leastone plate so that the at least one plate is retained thereon, wherein the at least one plate and the elongated central member are both formed of materials that produce molybdenum-99 (Mo-99) by way ofneutron capture.

This invention provides a preparation method for zirconium thin films. A dual ion beam epitaxy apparatus with the function of mass separation and characteristics of energetic ion deposition is adopted and zirconium chloride of which purity is not highly required serves as raw materials and is sputtered to a sanitized substrate with single isotopic pure low-energy argon ion beam. First, a thin film of zirconium nitride as block layer and buffer layer preventing reactions between zirconium ion and the substrate is prepared with the consequent isotopic pure low-energy zirconium ion beam and nitrogen ion beam, and then a zirconium film is deposited by epitaxy of single isotopic pure low-energy zirconium ion beam. By exactly controlling the energy of zirconium ion beam, the amount of deposition agents, beam density, beam shape and growing temperature, low-cost deposition and low-temperature epitaxy of zirconium which has a high melting point and is difficult to purify can be realized in ultravacuum cultivation room with high purity and high crystallization quality. This technique is convenient to modulate and optimized and is economical to manufacture zirconium thin films.

The invention relates to the field of oilfield development, and provides a device and a method for nested layered injection of isotopic tracers. The device comprises an injection container, a water injection pipeline, and valves, and also comprises a sleeve, an oil pipe, a central pipe, and a packer. In the method, through controlling the switches of the valves, the isotopic tracer is injected into corresponding oil layers respectively through the sleeve, the oil pipe, and the central pipe, so as to realize layered injection of the isotopic tracer. The nested layered injection device and the layered injection method realize layered injection of different kinds of isotopic tracers, and injection volume of the isotopic tracer of each oil layer is accurately controlled, accurate monitoring of the isotopic tracer of each oil layer is realized. The device and the method have significant value for determining oil reservoir parameter distribution, reservoir exploitation evaluation, follow-up development scheme design determination, adjustment, and implementation.

Method and apparatus for detecting, by absorption spectroscopy, an isotopic ratio of a sample, by passing first and second laser beams of different frequencies through the sample. Two IR absorption cells are used, a first containing a reference gas of known isotopic ratio and the second containing a sample of unknown isotopic ratio. An interlacer or reflective chopper may be used so that as the laser frequencies are scanned the absorption of the sample cell and the reference cell are detected alternately. This ensures that the apparatus is continuously calibrated and rejects the baseline noise when phase sensitive detection is used.

The invention relates to the field of oil field exploitation, and provides an isotopic tracer layered injection device and method for a multi-zone oil reservoir. The device comprises an injection container, a water injection pipeline, and a valve. The device also comprises N packers and (N+1) eccentric water distributors, wherein the packers are respectively disposed between each two eccentric water distributors. The device also comprises quantitative water nozzles and dead plugs, which are used cooperatively with the eccentric water distributors. The device also comprises the (N+1) quantitative water nozzles. The method comprises the steps: enabling the quantitative water nozzle of one eccentric water distributor to be replaced by one dead plug; enabling the remaining eccentric water distributors to be communicated with an oil layer; slowly injecting isotopic tracer through the control of the opening / closing of the valve; and enabling the isotopic tracer to be injected into a target oil layer. The device and method can achieve the layered injection of different types of isotopic tracers, precisely control the injection amount of isotopic tracer at each oil layer, achieve the accurate monitoring of the isotopic tracer of each oil layer, and has great values for the determining of oil reservoir parameter distribution, reservoir development evaluation, the determining of the design, adjustment and execution of a subsequent development scheme.

The invention discloses a method and a device for determining the molecular weight of a compound. The method comprises the following steps: acquiring a mass spectrogram of a sample and determining anisotope ion peak; determining a candidate range of the molecular weight of the sample based on the isotope ion peak; obtaining a candidate molecular formula of the sample according to the candidate range of the molecular weight of the sample; comparing the candidate molecular formulas with a pre-created isotope standard library to obtain a similarity result of the sample and a standard compound inthe isotope standard library, the isotope standard library comprising molecular formulas screened based on an isotope principle; and determining the molecular weight of the sample based on the similarity result. Similarity comparison is carried out on the organic matter to be detected and isotope distribution to determine the molecular weight of the organic matter, the detection sensitivity is improved, the compound quantification limit and detection limit are reduced, and the compound molecular weight detection accuracy is improved.

A composition adapted for mass spectral analysis is disclosed as are methods of its use in mass spectral analyses. A contemplated composition contains a mass spectrally-determinable amount of each of (i) at least one analyte to be assayed and (ii) a standard compound. Each of the molecules of the standard compound contains one or the other of a pair of two stable isotopes of the same element that differ in molecular weight by at least two atomic mass units. Those two isotopes are present in the molecules of the standard compound in a predetermined ratio that is other than the naturally occurring ratio of those isotopes.

The invention provides a research method for simulating an SF6 overheat decomposition reaction based on a stable isotopic tracer method, which comprises the following steps of: constructing an SF6 insulation equipment local overheat experiment platform, controlling a fault temperature by using a temperature controller, and researching accurate injection of H218O and 18O2 with different concentrations. The method comprises the following steps: removing the influence of impurities in the air and impurities remaining on the surface of an experimental apparatus on the experiment, heating for a period of time, collecting the reacted mixed gas in the experimental apparatus, and analyzing the proportion of gas components and isotope compounds by GC / MS, thereby researching the interaction of trace oxygen and water and SFx in the SF6 thermal decomposition process. And analyzing the formation mechanism of the SF6 decomposition product. The experimental platform is designed according to the internal overheating fault condition of the gas insulation equipment so as to simulate the decomposition condition of SF6 under an actual fault.

Heteronuclear radioisotope nanoparticle of core-shell structure and a preparation method thereof are provided. The Heteronuclear radioisotope nanoparticle of core-shell structure comprising core of two different radioisotopes selected from a group consisting of 198Au, 63Ni, 110mAg, 64Cu, 60Co, 192Ir and 103Pd, and a shell comprising Si02 surrounding the core.The Heteronuclear radioisotope nanoparticle of core-shell can be used as a tracer for the purpose of detecting variation of volume ratio or for the evaluation of the behavior characteristic of a water resource, based on information about phase ratio in the flow of multiphase fluid existing in a process which is operated under extreme condition such as high temperature and / or high pressure conditions.

Systems and methods for determining the thermal maturity of a rock formation from isotopic values in gases are provided. Isotope values may be obtained from mud gas isotope logging, vitrinite reflectance equivalence values may be determined from core samples using known techniques. A relationship between vitrinite reflectance equivalence and isotopic values, such as carbon-13 methane values, may be determined. The vitrinite reflectance equivalence may then be determined from isotopic values to determine the thermal maturity of rock formations accessed by drilling additional exploration wells.

A method for isotope measurement of charged species contained in a solution to be analyzed, particularly charged species having an isobaric interference, has the following consecutive steps:a) in the capillary of a capillary electrophoresis device, the solution to be analyzed is inserted contiguously between a terminating electrolyte and a leading electrolyte that, respectively, are placed after the inlet and before the outlet of the capillary and contain ions of the same charge but with mobility inferior and superior to those of said species;b) separating the species by using the capillary electrophoresis device according to the isotachophoresis mode; thenc) in the continuity of the preceding step, performing an isotope measurement of the species detected in the form of a substantially constant amplitude signal by using an inductively coupled plasma mass spectrometer (ICPMS) connected by direct coupling with the capillary electrophoresis device.

The invention relates to an indolizine derivative and an application thereof in medicines, concretely discloses a novel substituted indolizine derivative of general formula I, or an isotopically labeled compound thereof, or an optical isomer, a geometric isomer or a tautomer thereof or a mixture of above isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, and also relatesto the application of above compounds in the field of medicines.

A method for determining a hydrocarbon concentration from drilling fluid includes pumping the drilling fluid into a wellbore and circulating a sample of the drilling fluid uphole from the wellbore so that δ13C isotopic signatures can be determined for one or more hydrocarbon components and for methane in the sample where the methane includes natural methane originating from the earth formation and artificially-produced methane caused by drill bit metamorphism (DBM). A processor is adapted to determine the concentration of the natural methane in the sample based in part on the δ13C isotopic signatures which may be performed during the drilling of the wellbore.