10 results about "Isotopomers" patented technology

The invention relates to psychoactive medicines including methylone, 2C-B, MBDB, their respective salts, metabolites, isomers, enantiomers, solvates, isotopologues and isotopomers, polymorphs, prodrugs and analogs (2C-series and cathinones); their preparation, formulations, intermediates, routes of administration, dosing and schedule for medical uses for psychiatric and neurological conditions and disorders.

This application belongs to the field of environmental analytical chemistry and environmental geochemistry, and specifically discloses a molecular formula matching method for Fourier transform ion cyclotron resonance mass spectrometry, including: calculating all possible candidate molecular formulas based on the mass spectrometric information of dissolved organic matter samples determined by FT-ICR MS; identifying double-charged molecular formulas based on the double-charge recognition rule; and based on... 18 O-marking validation rules, filtering out initially valid entries containing... 18 O candidate molecular formula; based on 13 C / 12 C 34 S / 32 S and 15 N / 14 The isotopic patterns of N were used to eliminate false positive molecular formulas; the optimal molecular formula for each mass spectral peak was determined from the remaining candidate molecular formulas, and the optimal formula was determined based on the double charge recognition rule and... 18 O-labeling verification rules, for double-charged molecular formulas and those containing O-labeling in the optimal molecular formula. 18 The molecular formula of O was re-verified. This application enables the verification of molecules containing O. 18 The high accuracy of matching between O-labeled molecules and double-charged molecules improves the accuracy of molecular formula matching.

Provided herein are compositions comprising macromolecular photocleavable prodrug compounds of Formula (I), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, and isotopically enriched derivatives thereof. Also provided are methods, uses, pharmaceutical compositions, and kits involving the inventive compounds or compositions for treating and / or preventing a disease and / or condition (e.g., inflammatory disease, infectious disease, pain) in a subject, optionally comprising illumination of the compound, composition, or pharmaceutical composition with light of an absorption wavelength sufficient to cleave the bonds between each instance of L and each instance of X upon illumination with the light (e.g., light between approximately 200 nm to 500 nm).

The application belongs to the technical field of analytical testing and substance component detection, and specifically discloses a novel compound identification method based on atlas analysis of a combined instrument, which comprises the following steps: synchronously aligning the chromatographic retention time, ion drift time, mass-to-charge ratio and ion abundance of a sample to be detected to extract a four-dimensional characteristic peak group; based on an addition rule, gathering ion clusters to confirm a single isotopic mass; calculating a mass offset and matching a conversion reaction dictionary to anchor a candidate metabolite; comparing secondary mass spectrum fragments and mapping to a parent fragmentation path to generate a two-dimensional plane structure; based on this, enumerating isomers, constructing a three-dimensional rigid body molecular model and deducing a theoretical collision cross section area; finally, comparing the actually measured and theoretical collision cross section areas, combining the polarity difference of the retention time mapping to perform orthogonal constraint verification, and outputting the target three-dimensional structure of the metabolite. The application realizes the reliability of compound confirmation in a complex sample.

A method and system for isotopically separating lithium-6 and lithium-7 from a mixture of lithium-6 and lithium-7. The method involves using molecular distillation with heat exchange means supplied by a nuclear reactor (1) for efficient separation of isotopes. The system comprises a molecular distillation apparatus with a distiller (20) and incorporates a nuclear reactor (1) equipped with heat exchange means to provide the heat required for the process.

The present disclosure relates to the technical field of biomedicine, and in particular to an ionizable lipid compound having a structure represented by the following formula (I) or a pharmaceutically acceptable salt, solvate, isotopic variant, tautomer or stereoisomer thereof, or a use thereof, wherein n1, n2, n3 and n4 are each independently an integer from 1 to 20. Further provided is a preparation method for the ionizable lipid compound.

The utility model discloses a kind of isotopic tracing soil culture devices in situ in field, solve the problems such as high isotope loss of traditional device, environmental simulation distortion and cumbersome operation etc..The isotopic tracing soil culture device, including split type pipe body, by split type pipe body using left, right semicircular pipe body's movable inlay, reduce the structure damage to in-situ soil when sampling;By setting upper end cap and lower end cap respectively in the upper and lower ends of split type pipe body, fixed split type pipe body also make the closed circulation inside culture tube, prevent isotope leakage.Several through-holes are set in the pipe wall of split type pipe body and corresponding filter membrane is provided to realize the distribution and diffusion of isotope control;By setting lifting component, manual use is facilitated.

This invention relates to the preparation and use of a phenylpyrazole derivative. Specifically, this invention relates to an N-substituted phenylpyrazole derivative of formula (I) or its isotopically labeled compound, or its optical isomers, geometric isomers, tautomers, or mixtures of isomers, or its agronomically acceptable salt, and the use of said compound in the preparation of insecticides for pest control. Such compounds can achieve better pest control effects at lower dosages, particularly against pests of the orders Lepidoptera, Coleoptera, Homoptera, Hemiptera, Thysanoptera, Isoptera, Diptera, Hymenoptera, Trichophyton, Pseudocoptera, Orthoptera, Blattodea, Silicaria, Acari, and Nematodes.

The application relates to a sampling and chlorine removing method and device for salt lake water soluble organic carbon isotope mass spectrum determination, and relates to a chlorine ion concentration determination method for salt lake water samples. If the chlorine ion concentration of the salt lake water sample is equal to or lower than the upper limit set value of the chlorine removing device, the gas sample prepared from the salt lake water sample is removed of chlorine through the chlorine removing device; the device is a filtering tube with a plurality of axial parallel silver wire bundle filters connected in series with a sampling needle capillary; the filtering tube is used in positive and reverse directions; if the chlorine ion concentration of the water sample is higher than the upper limit set value, the chlorine ion concentration of the water sample is reduced to below the upper limit set value through a chemical precipitation method, and then the chlorine is removed through the chlorine removing device. The method has the advantages of fully exerting the advantages of chemical precipitation in removing a large amount of chlorine, avoiding the adverse effects of AgNO3 excess on the water sample during chemical precipitation, avoiding the limitation of the filter in removing chlorine, and significantly reducing the cost of the silver wire in removing chlorine.