The invention discloses an organic electroluminescent device comprising an anode conductive substrate, a hole injection layer, a hole transporting layer, a light-emitting layer, an electron transporting layer, an electron injection layer, a cathode layer, an organic blocking layer, an inorganic blocking layer, a moisture absorption layer and a cooling layer which are stacked successively. According to the organic electroluminescent device, the material of the inorganic blocking layer adopts a mixture of telluride and sulfide, so advantages, such as high density, good water and oxygen prevention capability, etc., can be realized, and the material of the moisture absorption layer is selected from at least one calcium oxide, barium oxide, strontium oxide and magnesium oxide, so the water vapour in the air can be absorbed. Through the cooperation of the inorganic blocking layer and the moisture absorption layer, less water vapour and oxygen enter the organic electroluminescent device, and compared with a conventional organic electroluminescent device, the organic electroluminescent device has the advantage of long service life. The invention further discloses a preparing method of the organic electroluminescent device.