The invention discloses a desktop five-degree-of-freedom micro-compound processing machine tool, which includes a workpiece rotation module, a tool module, a control system, an X-direction drive module, a Y-direction drive module, and a Z-direction drive module. The workpiece rotation module includes a swing table, A clamping device and a rotary drive device for driving the swing table to swing, the clamping device includes a turning fixture and / or a milling fixture, and the milling fixture is fixed by a turning fixture; the tool module includes a turning tool holder and A plurality of turning tools arranged on the turning tool holder, the turning tools move to the clamping device under the synergy of the X-direction driving module, the Y-direction driving module and the Z-direction driving module, so as to realize the workpiece to be processed on the clamping device processing. Utilizing the invention helps to reduce redundant productivity or idle functions of machine tools, reduce manufacturing energy consumption and cost, improve the processing quality of micro devices, and accelerate the process of systematization, integration and intelligence of product manufacturing.