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39results about How to "Achieve high density" patented technology

Micro-vessel liver chip based on cell clusters and making method and using method thereof

The invention discloses a micro-vessel liver chip based on cell clusters. The micro-vessel liver chip comprises a micro-vessel system located on the upper layer, a blood-vessel-endothelium-like barrier system in the middle and a liver-organ multi-cell co-culture system on the lower layer, wherein the micro-vessel system and the liver-organ multi-cell co-culture system are arranged on own substrates respectively. The micro-vessel system comprises a bent vessel composed of multiple flow-stopping barriers in a staggered mode, and a micro-vessel inlet and a micro-vessel outlet are formed in the two ends of the bent vessel respectively. The blood-vessel-endothelium-like barrier system is composed of a porous film. The liver-organ multi-cell co-culture system comprises a cell cluster enrichment region and a multi-cell co-culture region, and a culture system inlet and a culture system outlet are formed in the two ends of the liver-organ multi-cell co-culture system respectively. A liver disease model can be established, research on pharmacokinetics and medicine activity can be performed, and the micro-vessel liver chip has the advantages of using a small quantity of samples, achieving medicine low consumption and being portable, economical, efficient and accurate.
Owner:SOUTHEAST UNIV

Packaging and interconnecting structure and method for copper protruded points filled up with double layers of underfill

The invention relates to a packaging and interconnecting structure and method for copper protruded points filled up with double layers of underfill. The packing and interconnecting structure is characterized in that the chip end is filled up with the first layer of underfill, the first layer of underfill is manufactured on a wafer through spin coating process, the substrate end is filled up with the second layer of underfill, the substrate end is filled through capillary effects after flip-chip welding is finished, the glass transition temperature and the Young modulus of the first layer of underfill are lower than those of the second layer of the underfill, a chip and a substrate are connected through the copper protruded points and tin-contained solder protruded points to achieve high-density connection, and the copper protruded points are manufactured in twice to guarantee that the first layer underfill is completely filled and the contact between the protruded points and the tin-contained solder is enough. The whole technological process is compatible with existing IC process and has higher vertical interconnection density, better electric connection characteristics and higher mechanical stability. Heating thermal circulation tests show that the service life of chips of the packaging structures is greatly prolonged.
Owner:SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI

Micro-stirring friction welding process for electronic packaging

The invention discloses a micro-stirring friction welding process for electronic packaging and belongs to the technical field of electronic packaging. The problem that an existing electronic packagingtechnology is not ideal in densification and pollution freeness achieving effect and the problem that an existing stirring friction welding technology can hardly achieve direct welding on micro, small and thin structures. Firstly, a first bonding pad and a second bonding pad to be welded serve as a welding pad set; when the welding pad set is arranged at single points, a press-in hole is prefabricated and machined in a first substrate, the welding pad set is arranged between the first substrate and a second substate in parallel, the press-in hole and the center position of the welding pad setare arranged in a centering manner, and then the first substrate and the second substrate are compressed through a clamp; and a stirring head is coaxially aligned to the upper portion of the press-inhole, the stirring head is controlled to rotate at high speed and move downwards into the press-in hole and then is pressed into the first welding pad; and under the set press-in amount and holding time, the permanent metallurgy connection of the first welding pad and the second welding pad is achieved, and finally the stirring head is controlled to move out of the press-in hole upwards.
Owner:HARBIN INST OF TECH

Copper bump package interconnection structure and method filled with double-layer underfill glue

The invention relates to a packaging and interconnecting structure and method for copper protruded points filled up with double layers of underfill. The packing and interconnecting structure is characterized in that the chip end is filled up with the first layer of underfill, the first layer of underfill is manufactured on a wafer through spin coating process, the substrate end is filled up with the second layer of underfill, the substrate end is filled through capillary effects after flip-chip welding is finished, the glass transition temperature and the Young modulus of the first layer of underfill are lower than those of the second layer of the underfill, a chip and a substrate are connected through the copper protruded points and tin-contained solder protruded points to achieve high-density connection, and the copper protruded points are manufactured in twice to guarantee that the first layer underfill is completely filled and the contact between the protruded points and the tin-contained solder is enough. The whole technological process is compatible with existing IC process and has higher vertical interconnection density, better electric connection characteristics and higher mechanical stability. Heating thermal circulation tests show that the service life of chips of the packaging structures is greatly prolonged.
Owner:SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI

A kind of microvascular liver chip based on cell aggregates and methods of making and using the same

The invention discloses a micro-vessel liver chip based on cell clusters. The micro-vessel liver chip comprises a micro-vessel system located on the upper layer, a blood-vessel-endothelium-like barrier system in the middle and a liver-organ multi-cell co-culture system on the lower layer, wherein the micro-vessel system and the liver-organ multi-cell co-culture system are arranged on own substrates respectively. The micro-vessel system comprises a bent vessel composed of multiple flow-stopping barriers in a staggered mode, and a micro-vessel inlet and a micro-vessel outlet are formed in the two ends of the bent vessel respectively. The blood-vessel-endothelium-like barrier system is composed of a porous film. The liver-organ multi-cell co-culture system comprises a cell cluster enrichment region and a multi-cell co-culture region, and a culture system inlet and a culture system outlet are formed in the two ends of the liver-organ multi-cell co-culture system respectively. A liver disease model can be established, research on pharmacokinetics and medicine activity can be performed, and the micro-vessel liver chip has the advantages of using a small quantity of samples, achieving medicine low consumption and being portable, economical, efficient and accurate.
Owner:SOUTHEAST UNIV
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