The invention discloses a packaging method of a full-color LED display module. The method comprises the steps of 1, coating the package resin on a separation film; 2, placing a separation plate on a first jig, and placing the separation film coated with the package resin on the separation plate, wherein the side of the separation film with the package resin is placed upwards; 3, placing the solid-crystal full-color LED display module substrate on the package resin, placing the chip of a full-color LED display module substrate to be downwards, and then placing a second jig; 4, combining the first jig and the second jig, and putting the first jig and the second jig into a vacuum air compressor for vacuum lamination; 5, after the lamination is completed, taking out the full-color LED displaymodule substrate, tearing off the separation film, and finishing the packaging operation. Correspondingly, the invention further provides a full-color LED display module and a display screen of the full-color LED display module. By the adoption of the method, the diversified selection of packaging sizes and packaging materials can be realized. The packaging quality is good, and the foaming is avoided. The requirement on packaging equipment is low.