The invention provides an acid-base neutralization reaction device for water pollution control, which comprises a box body, a first bearing is fixedly sleeved in the upper end of the box body, a rotating drum is fixedly sleeved in the first bearing, a second bearing is fixedly sleeved in the rotating drum, a driving shaft is fixedly sleeved in the second bearing, a first bevel gear is fixedly connected to the outer side of the rotating drum, a second bevel gear is fixedly connected to one end of the driving shaft, a servo motor is fixedly connected to the outer side of the box body, a third bevel gear is fixedly connected to the tail end of an output shaft of the servo motor, a round pipe is fixedly connected to the interior of the box body, and a water inlet pipe is fixedly connected to the round pipe. The round pipe, a spray head, a water pump and other structures are additionally arranged in the box body, when water enters a sewage pipe, reaction liquid in a liquid box can be conveyed into the spray head through the water pump and then sprayed out, and therefore the reaction liquid can be added more evenly.