The invention aims at the problems of low efficiency, poor consistency, unclean cleaning and easiness in destroying a to-be-destroyed substrate or a radar electronic component of manual large-scale cleaning. The invention provides an acoustic vibration brush, which comprises a handle, a rechargeable battery compartment, a switch, a rechargeable battery, an acoustic transducer, a vibration bar, a brush head sleeve and bristle. The invention provides a cleaning method, which comprises the six steps of installing, injecting cleaning fluid for the first time, cleaning, carrying out visual inspection, injecting the cleaning fluid for the second time and cleaning, and blowing. The acoustic vibration brush and the cleaning method which are provided by the invention have the beneficial technical effects that an acoustic vibration manner is adopted to drive the bristle to clean the vibration sensitive ceramic substrate or the radar electronic component at short time and high frequency, so that the cleaning efficiency is improved, the operation fatigue is alleviated and the cleaning effect consistency is guaranteed.