The invention relates to a preparation method of a high-activity red mud-based concrete admixture, belonging to a preparation method of a composite activated mineral admixture. The preparation method comprises the steps of: by taking red mud as main raw materials and industrial waste slag of carbide slag, desulfurization gypsum and the like as auxiliary materials, performing heating power activation through the self combustion heat of unburned coal gangue to obtain the high-activity red mud-based concrete admixture, wherein in the process of blending concrete materials, 20% by weight of the red mud composite replaces PO52.5, or PO42.5, or PC32.5 portland cement, under the condition of keeping other blending materials, the cost of per cubic meter concrete blended can be saved greatly, the strength of the blended concrete in each age is equal to or higher than that of the compared concrete, and the newly blended concrete has the characteristics of being good in peaceability, small in slump loss, low in hydration heat, good in later strength transitivity, sulfate corrosion-resistant, strong in chemical corrosion resistance, and good in durability, having no adverse influence on the property of the concrete, and the like.